{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:53:12Z","timestamp":1781502792948,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphomas (MCLs) are the prototypic B\u2010cell non\u2010Hodgkin lymphomas defined by cyclin D1 gene (\n                    <jats:italic>CCND1;<\/jats:italic>\n                    or other cyclin D family gene) rearrangements. However, extremely rare cases of diffuse large B\u2010cell lymphomas (DLBCLs) harboring\n                    <jats:italic>CCND1<\/jats:italic>\n                    rearrangements, resulting in cyclin D1 protein expression, have also been reported. In this report, we describe an unusual primary large B\u2010cell lymphoma of non\u2010germinal center immunophenotype of the central nervous system (CNS) in an elderly male patient, which was negative for CD5 and SOX11, and exhibited cyclin D1 expression. Fluorescence in situ hybridization analysis detected\n                    <jats:italic>IGH\u2010<\/jats:italic>\n                    <jats:italic>CCND1<\/jats:italic>\n                    and\n                    <jats:italic>BCL6<\/jats:italic>\n                    rearrangements. This case may represent the first report of a primary CNS DLBCL with\n                    <jats:italic>IGH\u2010<\/jats:italic>\n                    <jats:italic>CCND1<\/jats:italic>\n                    rearrangement. The clinico\u2010pathologic features that can help differentiate primary CNS MCL from primary DLBCL of the CNS with\n                    <jats:italic>IGH\u2010<\/jats:italic>\n                    <jats:italic>CCND1<\/jats:italic>\n                    rearrangement are discussed.\n                  <\/jats:p>","DOI":"10.1002\/hon.2779","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T09:19:35Z","timestamp":1594199975000},"page":"817-822","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary large B\u2010cell lymphoma of the central nervous system with cyclin\n                    <scp>D1<\/scp>\n                    expression and t(11;14) (\n                    <i>IGH\u2010<\/i>\n                    <i>\n                      <scp>CCND1<\/scp>\n                      )\n                    <\/i>\n                    : Diffuse large B\u2010cell lymphoma with\n                    <i>\n                      <scp>CCND1<\/scp>\n                    <\/i>\n                    rearrangement or mantle cell lymphoma?"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-7479","authenticated-orcid":false,"given":"Andrew M.","family":"Parrott","sequence":"first","affiliation":[{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya M.","family":"Haggiagi","sequence":"additional","affiliation":[{"name":"Department of Neurology &amp; Herbert Irving Comprehensive Cancer Center Vagelos College of Physicians and Surgeons, New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vundavalli V.","family":"Murty","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Bhagat","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bachir","family":"Alobeid","sequence":"additional","affiliation":[{"name":"Department of Pathology and Cell Biology Vagelos College of Physicians and Surgeons, New York\u2010Presbyterian Hospital\/Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2010.540361"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2008.03042.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3735"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61272"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010568"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPUIDW2CPTA1JA"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000120"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068343"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqz138"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.46.9957"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756285608101222"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.357"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2020.02.001"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.1455"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07835.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.1316"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069080"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.46.3.824"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0368-OA"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0b013e3181bb9edf"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13286"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(95)90090-X"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.010264"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2013.141"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28664"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000128671.92609.af"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314608110"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm447"}],"container-title":["Hematological 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