{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T05:53:09Z","timestamp":1781502789485,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,8,19]],"date-time":"2020-08-19T00:00:00Z","timestamp":1597795200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Non\u2010chronic lymphocytic leukemia (non\u2010CLL) clonal B\u2010cell lymphocytosis (CBL) encompasses a heterogeneous group of hematologic disorders that are still poorly understood. To shed light on their biological aspects, we retrospectively analyzed a highly selected series of 28 patients, who had a clonal B\u2010cell population in the peripheral blood and in the bone marrow, without evidence of lymphoma. Extended targeted next\u2010generation sequencing revealed wide molecular heterogeneity with\n                    <jats:italic>MYD88<\/jats:italic>\n                    (14%),\n                    <jats:italic>PDE4DIP<\/jats:italic>\n                    (14%),\n                    <jats:italic>BIRC3<\/jats:italic>\n                    (11%),\n                    <jats:italic>CCND3<\/jats:italic>\n                    (11%),\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    (11%), and\n                    <jats:italic>TNFAIP3<\/jats:italic>\n                    (11%) as the most mutated genes. Mutations of MYD88 were \u201cnonclassic\u201d in most cases. Although some genetic lesions were overlapping with indolent lymphomas, mainly splenic B\u2010cell lymphomas of marginal zone origin and splenic diffuse red pulp small B\u2010cell lymphoma, the genetic profile of our non\u2010CLL CBL series seemed to suggest that various pathways could be involved in the pathogenesis of these disorders, not mirroring any specific lymphoma entity. These data better enlighten the molecular characteristics of non\u2010CLL CBL; however, more efforts are needed in order to improve the diagnostic process, prognostication, and clinical management.\n                  <\/jats:p>","DOI":"10.1002\/hon.2784","type":"journal-article","created":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T12:48:59Z","timestamp":1596286139000},"page":"689-697","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Targeted next\u2010generation sequencing reveals molecular heterogeneity in non\u2010chronic lymphocytic leukemia clonal B\u2010cell lymphocytosis"],"prefix":"10.1002","volume":"38","author":[{"given":"Irene","family":"Defrancesco","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine University of Pavia  Pavia 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