{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:55:33Z","timestamp":1784580933663,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Patients with autoimmune diseases (AIDs) may develop lymphoproliferative disorders (LPDs) during treatment with immunosuppressive agents (IS) such as methotrexate (MTX), biological agents, or tacrolimus. Some LPDs in patients with AIDs (AID\u2010LPDs) regress after withdrawal of IS, and a high incidence of Epstein\u2013Barr virus (EBV) positivity in such patients has been reported. To identify characteristics and factors predictive of the response to treatment and disease progression, we retrospectively analyzed clinical and histopathological data for 81 patients with AID\u2010LPDs. Almost all of them (96%) had been treated with MTX. Diffuse large B cell lymphoma was the most common LPD type (61%) and seven patients (9%) had classical Hodgkin lymphoma (CHL). EBV was detected by in situ hybridization with an EBV\u2010encoded small RNA (EBER) probe in 43% of the examined cases. In 59 patients, IS was discontinued as the initial treatment, resulting in regression of LPDs in 69% of them, and multivariate analysis showed that EBER positivity was an independent factor predictive of such regression (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.022). Two\u2010year progression\u2010free survival (PFS) and overall survival for the patients overall were 63% and 83%, respectively. Poor PFS was associated with advanced stage (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.024), worse performance status (PS,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.031), CHL histology (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.013), and reactivation of EBV\u2010related antibodies (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.029). In conclusion, EBV positivity demonstrated using an EBER probe is useful for prediction of successful regression after withdrawal of IS in patients with AID\u2010LPDs. Patients with advanced stage disease, worse PS, CHL histology, or reactivation of EBV\u2010related antibodies should be closely monitored after initial treatment.\n                  <\/jats:p>","DOI":"10.1002\/hon.2790","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T05:29:26Z","timestamp":1597469366000},"page":"799-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of Epstein\u2013Barr virus with regression after withdrawal of immunosuppressive drugs and subsequent progression of iatrogenic immunodeficiency\u2010associated lymphoproliferative disorders in patients with autoimmune diseases"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1643-0390","authenticated-orcid":false,"given":"Katsuya","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Hematology Graduate School of Medicine Hokkaido University  Sapporo Hokkaido Japan"},{"name":"Department of Hematology National Hospital Organization Hokkaido Cancer Center  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako C.","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Hatanaka","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Hokkaido University Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Department of Hematology Sapporo City General Hospital  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Hematology Sapporo 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