{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T12:54:20Z","timestamp":1784984060337,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2020,9,5]],"date-time":"2020-09-05T00:00:00Z","timestamp":1599264000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the years, the prognosis of adolescents treated for acute lymphoblastic leukemia (ALL) has improved. However, this age group still represents a challenge with an overall survival (OS) of 60% compared to 85% in younger children. Herein, we report the outcome of adolescents treated in the European Organisation for Research and Treatment of Cancer (EORTC) 58951 clinical trial. EORTC 58951 clinical trial included patients with de novo ALL between 1998 and 2008. For this study, we analyzed data of all adolescents between 15 and under 18. Data from 97 adolescents were analyzed, 70 had B\u2010lineage and 27 had T\u2010lineage ALL. The 8\u2010year event\u2010free survival (EFS) and OS for the B\u2010cell precursor ALL cases were 72.3% (59.4%\u201381.7%) and 80.8% (67.4%\u201389.1%), respectively. For the T\u2010lineage, the 8\u2010year EFS and OS were 57.4% (36.1%\u201374.0%) and 59.0% (36.1%\u201376.2%), respectively. \u201cB\u2010other\u201d ALL, defined as BCP\u2010ALL lacking any known recurrent genetic abnormalities were more frequent in our adolescent population (52.8%) than in younger children (27.1%). Outcome of adolescents in the EORTC 58951 study is supporting the findings that adolescents have better outcome in pediatric compared to adults' trials. Nevertheless, in pediatric studies, adolescents still have a worse prognosis than younger children. Despite the fact that specific unfavorable characteristics may be linked to the adolescent population, a careful study and characterization of adolescents \u201cB\u2010other\u201d genetic abnormalities in ALL is critical to improve the outcome of this population.<\/jats:p>","DOI":"10.1002\/hon.2791","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T08:53:05Z","timestamp":1598604785000},"page":"763-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pediatric randomized trial EORTC CLG 58951: Outcome for adolescent population with acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2908-5768","authenticated-orcid":false,"given":"Laura","family":"Olivier\u2010Gougenheim","sequence":"first","affiliation":[{"name":"Institute of Pediatric Hematology and Oncology Hospices Civils de Lyon Claude Bernard Lyon I University  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