{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:55:33Z","timestamp":1788195333552,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Chimeric antigen receptor\u2010T (CAR\u2010T) cell therapy is a promising treatment for CD19\n                    <jats:sup>+<\/jats:sup>\n                    B\u2010cell malignancies. However, elimination of B cells by anti\u2010CD19 CAR\u2010T cells may lead to the reactivation of hepatitis B virus (HBV) and related hepatitis in patients with HBV infection. This study aims to evaluate the safety and efficacy of humanized anti\u2010CD19 CAR\u2010T (hCAR\u2010T) therapy in B\u2010cell malignancies with HBV infection. Twenty relapsed\/refractory (r\/r) diffuse large B\u2010cell lymphoma (DLBCL) and acute lymphoblastic leukemia (ALL) patients with HBV infection were treated with hCAR\u2010T therapy. Among them, five hepatitis B antigen\u2010positive patients who received antiviral prophylaxis did not develop HBV reactivation, including two patients who received both hCAR\u2010T and allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). Among 15 patients with resolved HBV infection, two received antiviral prophylaxis, and the other 13 did not experience HBV reactivation without antiviral prophylaxis. One patient with resolved HBV infection experienced HBV reactivation 6 months after hCAR\u2010T therapy and sequential allo\u2010HSCT. Moreover, HBV infection did not affect in vivo expansion of hCAR\u2010T cells or increase the risk of severe cytokine release syndrome. In conclusion, hCAR\u2010T therapy is safe and effective in DLBCL and ALL patients with chronic and resolved HBV infection under proper antiviral prophylaxis.\n                  <\/jats:p>","DOI":"10.1002\/hon.2807","type":"journal-article","created":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T10:59:39Z","timestamp":1600513179000},"page":"75-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Humanized anti\u2010CD19 chimeric antigen receptor\u2010T cell therapy is safe and effective in lymphoma and leukemia patients with chronic and resolved hepatitis B virus infection"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4994-5262","authenticated-orcid":false,"given":"Rui","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital  Tianjin 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Therapy Shanghai Genbase Biotechnology Co., Ltd  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuxiang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology City of Hope National Medical Center  Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Hematology Tianjin First Central Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanfang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Lymphoma Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin\u2019s Clinical Research Center for Cancer  Tianjin 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