{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:02Z","timestamp":1772118662522,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Relapse and graft failure after autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT) are serious and frequently fatal events. A second HSCT can be a life\u2010saving alternative, however, information on the results of such intervention in an outpatient setting is limited. Outpatient second hematoprogenitors transplant after reduced\u2010intensity conditioning (RIC) at a single academic center was analyzed. Twenty\u2010seven consecutive adults who received an allo\u2010HSCT after an initial auto\u2010 or allo\u2010HSCT from 2006 to 2019 were included. Data were compared using the\n                    <jats:italic>\u03c7<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u2010test. Survival analysis using Kaplan\u2013Meier and Cox proportional hazard models was performed; cumulative incidence estimation of transplant\u2010related mortality (TRM) was assessed. Hodgkin lymphoma was the most frequent diagnosis for the group with a first auto\u2010HSCT with 5\/12 (41.7%) cases, and acute myeloid leukemia for those with a first allo\u2010HSCT with 6\/15 (40%). One\u2010year overall survival and disease\u2010free survival (DFS) was 66.7% (95% CI 27.2\u201388.2) and 59% (95% CI 16\u201386) for 12 patients with a first auto\u2010HSCT; and for 15 patients with a first allo\u2010HSCT, it was 43.3% (95% CI 17.9\u201366.5) and 36% (95% CI 13.2\u201359.9), respectively. Eight (29.6%) patients died of TRM and the cumulative incidence of TRM at 1 year was 22% (95% CI 8.6\u201339.27). Chronic graft\u2010versus\u2010host disease and late (&gt;10 months) second transplantation were protective factors for longer survival. Neutropenic fever was more common in the group with a first allo\u2010HSCT (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.01). In conclusion, outpatient second allo\u2010HSCT using RIC after auto\u2010 or allografting failure or relapse is feasible and offers a reasonable alternative for patients with severe life\u2010threatening hematological diseases.\n                  <\/jats:p>","DOI":"10.1002\/hon.2812","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T02:02:09Z","timestamp":1601085729000},"page":"87-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Outcomes of second hematopoietic stem cell transplantation using reduced\u2010intensity conditioning in an outpatient setting"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6804-9095","authenticated-orcid":false,"given":"Jos\u00e9 Carlos","family":"Jaime\u2010P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Hematology Internal Medicine Division Dr. Jose Eleuterio Gonzalez University Hospital and School of Medicine Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Pic\u00f3n\u2010Galindo","sequence":"additional","affiliation":[{"name":"Department of Hematology Internal Medicine Division Dr. Jose Eleuterio Gonzalez University Hospital and School of Medicine Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Herrera\u2010Garza","sequence":"additional","affiliation":[{"name":"Department of Hematology Internal Medicine Division Dr. Jose Eleuterio Gonzalez University Hospital and School of Medicine Universidad Autonoma de Nuevo Leon  Monterrey Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"G\u00f3mez\u2010Almaguer","sequence":"additional","affiliation":[{"name":"Department of Hematology Internal Medicine Division Dr. Jose Eleuterio Gonzalez University Hospital 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