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During an initial meeting, the areas of major concern in the management of CTCLs were selected by generating and rank\u2010ordering clinical key questions using the criterion of clinical relevance, through group discussion. Recommendations were achieved by multiple\u2010step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. The panel produced recommendations on how to facilitate the clinical suspicion of CTCL; indication of cutaneous biopsy; optimal histological diagnosis, immunohistochemistry and genetic markers; and staging pathway and up\u2010to\u2010date therapeutics (with particular focus on new treatments). The critical concept of integration of the different medical expertise in the management of the patients with CTCL was thoroughly examined. These recommendations are intended for use not only by expert centers but above all by \"not experienced\" dermatologists and hematologists as well as general practitioners.<\/jats:p>","DOI":"10.1002\/hon.2832","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T11:23:41Z","timestamp":1607858621000},"page":"275-283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Critical concepts and management recommendations for cutaneous T\u2010cell lymphoma: A consensus\u2010based position paper from the Italian Group of Cutaneous Lymphoma"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2112-2651","authenticated-orcid":false,"given":"Pier Luigi","family":"Zinzani","sequence":"first","affiliation":[{"name":"IRCCS Azienda Ospedaliero\u2010Universitaria di Bologna  Bologna Italy"},{"name":"Institute of Hematology \"L. e A. Ser\u00e0gnoli\" DIMES University of Bologna  Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Quaglino","sequence":"additional","affiliation":[{"name":"Department Medical Sciences Dermatologic Clinic University of Turin  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Alberti","family":"Violetti","sequence":"additional","affiliation":[{"name":"UOC Dermatology Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico University of Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Cantonetti","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology Department University \"Tor Vergata\"  Roma Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Goteri","sequence":"additional","affiliation":[{"name":"Anatomo\u2010Pathology Unit DISBSP University Politecnica delle Marche Ospedali Riuniti di Ancona  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Onida","sequence":"additional","affiliation":[{"name":"Hematology\u2013Bone Marrow Transplantation Center Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico \u2010 University of Milan  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Paulli","sequence":"additional","affiliation":[{"name":"Anatomo\u2010Pathology Unit University of Pavia  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serena","family":"Rupoli","sequence":"additional","affiliation":[{"name":"Clinic of Hematology Ospedali Riuniti Ancona  Ancona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Barosi","sequence":"additional","affiliation":[{"name":"Center for the Study of Myelofibrosis Laboratory of Biochemistry, Biotechnology and Advanced Diagnostics IRCCS Policlinico S. 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