{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:47:15Z","timestamp":1789015635632,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Nodular lymphocytic predominance Hodgkin lymphoma (NLPHL) is a very uncommon subtype of Hodgkin lymphoma (HL), representing approximately 5% of all HL cases, with an incidence of 0.3\/100,000 cases per year and with unique characteristics which distinguish it from classic Hodgkin lymphoma. Given its low frequency, there is a lack of prospective randomized studies to inform practice, the accumulated experience of academic groups being the main source of relevant information for the management of these patients. Eighty\u2010five patients recruited by the Spanish Lymphoma Group (GOTEL) from 12 different hospitals were retrospectively analyzed to describe their sociodemographic and clinical characteristics. The median follow\u2010up was 16 years, with a 10\u2010year overall survive of 92.9% and 81.2% at 20 years. Five patients developed a second malignancy. No transformation to a more aggressive lymphoma was detected. A total of 31% tumor relapses was found: 77% in a single location; most of them at a supra\u2010diaphragmatic level. Patients received different first\u2010line treatments, and progression was observed in 3\/4 (75%) of the patients who did not receive any type of treatment, 6\/23 (26%) who received both chemotherapy (CH) and radiotherapy (RT), 12\/43 (27%) who received RT and 7\/15 (47%) that received only CH treatment. The mean time to relapse was 3 years and 47% presented relapses beyond 5 years (higher probability in stage IV\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). This is one of the longest follow\u2010up series of NLPHL published, confirming its excellent prognosis, and that treatments may be adapted to reduce toxicity. Causes of death in these patients are varied, and the minority due to a primary malignancy relapses.\n                  <\/jats:p>","DOI":"10.1002\/hon.2835","type":"journal-article","created":{"date-parts":[[2020,12,30]],"date-time":"2020-12-30T03:03:31Z","timestamp":1609297411000},"page":"506-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term follow\u2010up of patients with nodular lymphocyte predominant Hodgkin lymphoma: A report from the Spanish Lymphoma Oncology Group"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2639-5162","authenticated-orcid":false,"given":"Beatriz","family":"N\u00fa\u00f1ez\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Hospital Puerta de Hierro  Majadahonda Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rodr\u00edguez\u2010Pertierra","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology HGU Gregorio Mara\u00f1\u00f3n  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Sequero","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Universitario Virgen de la Macarena  Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura G.","family":"Carvajal","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Ruano\u2010Ravina","sequence":"additional","affiliation":[{"name":"Preventive Medicine and Public Health Area CIBERESP Santiago de Compostela University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5623-9315","authenticated-orcid":false,"given":"David","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Universitario de Gran Canaria Dr Negr\u00edn  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Gum\u00e1","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Institut d'Oncologia de la Catalunya Sud Hospital Universitari Sant Joan de Reus IISPV\u2010URV  Tarragona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina Q.","family":"Blanco","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Hospital Universitario Virgen de la Victoria  M\u00e1laga Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco R.","family":"Garc\u00eda 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