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Pembrolizumab, a humanized anti\u2010PD\u20101 monoclonal antibody, binds PD\u20101 and blocks this interaction, enhancing the activity of the immune system against tumor cells, and has shown activity in PMBCL and in some cases of primary and secondary central nervous system (CNS) lymphoma. We report the case of a 40\u2010year\u2010old woman diagnosed with relapsed PMBCL and secondary CNS involvement who responded to pembrolizumab monotherapy, allowing for a later allogeneic stem cell transplant.<\/jats:p>","DOI":"10.1002\/hon.2836","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T16:48:08Z","timestamp":1609174088000},"page":"419-422","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pembrolizumab for refractory primary mediastinal B\u2010cell lymphoma with central nervous system involvement"],"prefix":"10.1002","volume":"39","author":[{"given":"Cristina","family":"de\u2010la\u2010Fuente","sequence":"first","affiliation":[{"name":"Department of Hematology Institut Catal\u00e0 d\u2019Oncologia\u2010Hospital Germans Trias i Pujol, Josep Carreras Research Institute  Badalona 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