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Recent large\u2010scale genome studies have uncovered multiple genetic alterations of FL that influence the microenvironment in two main directions, promoting tumor cell survival and proliferation and facilitating their evasion from immune antitumor signals. Understanding the crosstalk between tumor B\u2010cells and the microenvironment will facilitate the identification of vulnerabilities that may offer novel targets for treatment of the patients. This review highlights recent findings showing the effect of common genetic mutations modulating the cell composition of the tumor microenvironment and the novel therapeutic perspectives to target these interactions.<\/jats:p>","DOI":"10.1002\/hon.2855","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:14:29Z","timestamp":1623248069000},"page":"83-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Vulnerabilities in the tumor and microenvironment in follicular lymphoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Ferran","family":"Araujo\u2010Ayala","sequence":"first","affiliation":[{"name":"Department of Hematology\u2010Oncology Institut d'Investigacions Biom\u00e8diques August Pi I Sunyer (IDIBAPS)  Barcelona 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