{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:11:53Z","timestamp":1747149113906,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The treatment of classical Hodgkin lymphoma in young patients is one of the success stories of modern medicine. The use of risk\u2010 and response\u2010adapted approaches to guide treatment decisions has led to impressive cure rates while reducing the long\u2010term toxicity associated with more intensive therapies. Tissue biomarkers have not yet proven more effective than clinical characteristics for risk stratification of patients at presentation, but functional imaging features such as metabolic tumor volume may be used to predict response, if early observations can be validated. The success of treatment in younger patients has unfortunately not been mirrored in those over 60, where complex decision\u2010making is often required, with a paucity of data from clinical trials. The use of PD1 blocking antibodies and brentuximab vedotin in this cohort, either alone or in combination with chemotherapy, may provide attractive options. The incorporation of frailty assessment, quality\u2010of\u2010life outcomes, and specialist geriatric input is also important to ensure the best outcomes for this diverse group.<\/jats:p>","DOI":"10.1002\/hon.2856","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T14:14:29Z","timestamp":1623248069000},"page":"39-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Personalized medicine for Hodgkin lymphoma: Mitigating toxicity while preserving cure"],"prefix":"10.1002","volume":"39","author":[{"given":"Jemma","family":"Longley","sequence":"first","affiliation":[{"name":"Centre for Cancer Immunology CRUK Research Centre University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-4974","authenticated-orcid":false,"given":"Peter W. M.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Centre for Cancer Immunology CRUK Research Centre University of Southampton  Southampton UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,9]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1200\/JCO.2015.62.4817"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1016\/S0140-6736(17)32134-7"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1056\/NEJMoa1510093"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1016\/S2352-3026(20)30357-4"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1182\/blood-2017-07-795476"},{"doi-asserted-by":"publisher","key":"e_1_2_8_7_1","DOI":"10.1002\/hon.2437_18"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1200\/JCO.2016.34.15_suppl.7509"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.1182\/blood.2019000719"},{"doi-asserted-by":"publisher","key":"e_1_2_8_10_1","DOI":"10.1200\/JCO.2015.63.0699"},{"doi-asserted-by":"publisher","key":"e_1_2_8_11_1","DOI":"10.1182\/blood.2019003127"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1182\/blood-2019-123150"},{"doi-asserted-by":"publisher","key":"e_1_2_8_13_1","DOI":"10.1016\/S1470-2045(20)30601-X"},{"doi-asserted-by":"publisher","key":"e_1_2_8_14_1","DOI":"10.1016\/S1470-2045(18)30784-8"},{"doi-asserted-by":"publisher","key":"e_1_2_8_15_1","DOI":"10.1016\/S0140-6736(11)61940-5"},{"doi-asserted-by":"publisher","key":"e_1_2_8_16_1","DOI":"10.1182\/blood.2020008553"},{"doi-asserted-by":"publisher","key":"e_1_2_8_17_1","DOI":"10.1200\/JCO.19.00315"},{"doi-asserted-by":"publisher","key":"e_1_2_8_18_1","DOI":"10.1182\/blood.2020007400"},{"doi-asserted-by":"publisher","key":"e_1_2_8_19_1","DOI":"10.1182\/blood-2016-05-718528"},{"issue":"12","key":"e_1_2_8_20_1","first-page":"1369","article-title":"Hodgkin lymphoma in older patients: an uncommon disease in need of study","volume":"22","author":"Evens AM","year":"2008","journal-title":"Oncology"},{"doi-asserted-by":"publisher","key":"e_1_2_8_21_1","DOI":"10.1200\/JCO.2018.79.0139"},{"doi-asserted-by":"publisher","key":"e_1_2_8_22_1","DOI":"10.1182\/blood-2017-06-787200"},{"doi-asserted-by":"publisher","key":"e_1_2_8_23_1","DOI":"10.1182\/blood-2019-124866"},{"doi-asserted-by":"publisher","key":"e_1_2_8_24_1","DOI":"10.1016\/S2352-3026(20)30275-1"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2856","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T13:50:14Z","timestamp":1692885014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":23,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["10.1002\/hon.2856"],"URL":"https:\/\/doi.org\/10.1002\/hon.2856","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"type":"print","value":"0278-0232"},{"type":"electronic","value":"1099-1069"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"2021-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}