{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:45Z","timestamp":1772118525258,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007109","name":"Universit\u00e0 degli Studi di Ferrara","doi-asserted-by":"publisher","award":["FAR 2018, 2019, 2020"],"award-info":[{"award-number":["FAR 2018, 2019, 2020"]}],"id":[{"id":"10.13039\/501100007109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006694","name":"Associazione Italiana Contro le Leucemie - Linfomi e Mieloma","doi-asserted-by":"publisher","award":["Ferrara"],"award-info":[{"award-number":["Ferrara"]}],"id":[{"id":"10.13039\/501100006694","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Because the efficacy of new drugs reported in trials may not translate into similar results when used in the real\u2010life, we analyzed the efficacy of idelalisib and rituximab (IR) in 149 patients with relapsed\/refractory chronic lymphocytic leukemia treated at 34 GIMEMA centers. Median progression\u2010free survival (PFS) and overall survival were 22.9 and 44.5\u00a0months, respectively; performance status (PS) \u22652 and \u22653 previous lines of therapy were associated with shorter PFS and overall survival (OS). 48% of patients were on treatment at 12\u00a0months; the experience of the centers (\u22655 treated patients) and PS 0\u20131 were associated with a significantly longer treatment duration (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.015 and\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002, respectively). TP53 disruption had no prognostic significance. The overall response rate to subsequent treatment was 49.2%, with median OS of 15.5\u00a0months and not reached in patients who discontinued, respectively, for progression and for toxicity (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01). Treatment breaks \u226514\u00a0days were recorded in 96% of patients and adverse events mirrored those reported in trials. In conclusion, this real\u2010life analysis showed that IR treatment duration was longer at experienced centers, that the ECOG PS and \u22653 lines of previous therapy are strong prognostic factor and that the overall outcome with this regimen was superimposable to that reported in a randomized trial.\n                  <\/jats:p>","DOI":"10.1002\/hon.2861","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T08:30:59Z","timestamp":1616142659000},"page":"326-335","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of idelalisib and rituximab in relapsed\/refractory chronic lymphocytic leukemia treated outside of clinical trials. A report of the Gimema Working Group"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8370-5190","authenticated-orcid":false,"given":"Gian Matteo","family":"Rigolin","sequence":"first","affiliation":[{"name":"Department of Medical Sciences Hematology Section University of Ferrara  Cona \u2010 Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cavazzini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences Hematology Section University of Ferrara  Cona \u2010 Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Piciocchi","sequence":"additional","affiliation":[{"name":"GIMEMA Foundation  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Arena","sequence":"additional","affiliation":[{"name":"GIMEMA Foundation  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Visentin","sequence":"additional","affiliation":[{"name":"Department of Medicine Hematology and Clinical Immunology Unit University of Padua  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluigi","family":"Reda","sequence":"additional","affiliation":[{"name":"Ematologia, Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico di Milano  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Zamprogna","sequence":"additional","affiliation":[{"name":"Hematology Niguarda Cancer Centre ASST Grande Ospedale Metropolitano Niguarda  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Cibien","sequence":"additional","affiliation":[{"name":"Hematology, Ospedale Ca\u2019 Foncello  Treviso Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orsola","family":"Vitagliano","sequence":"additional","affiliation":[{"name":"Hematology Cardarelli Hospital  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Coscia","sequence":"additional","affiliation":[{"name":"Department of Molecular Biotechnology and Health Sciences University of Torino  Turin Italy"},{"name":"Division of Hematology A.O.U. Citt\u00e0 della Salute e della Scienza di Torino  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Farina","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Istituto Nazionale dei Tumori, Milano  Milano Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine Division of Hematology Universit\u00e0 del Piemonte Orientale  Novara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Murru","sequence":"additional","affiliation":[{"name":"Hematology and Stem Cell Transplantation Unit Ospedale Oncologico A. Businco ARNAS \u201cG. Brotzu\u201d  Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzia","family":"Varettoni","sequence":"additional","affiliation":[{"name":"Division of Hematology Fondazione IRCCS Policlinico San Matteo  Pavia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Paolini","sequence":"additional","affiliation":[{"name":"Hematology Unit Rovigo General Hospital  Rovigo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Sportoletti","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery Institute of Hematology and Centre for Hemato\u2010Oncological Research Ospedale S. Maria della Misericordia  Perugia Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Pietrasanta","sequence":"additional","affiliation":[{"name":"Hematology Division Dipartimento Internistico Struttura Complessa di Ematologia Ospedale civile SS Antonio e Biagio  Alessandria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Lia","family":"Molinari","sequence":"additional","affiliation":[{"name":"Hematology Ospedale degli Infermi  Rimini Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca M.","family":"Quaglia","sequence":"additional","affiliation":[{"name":"Department of Medicine Section of Hematology University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8327-1396","authenticated-orcid":false,"given":"Luca","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Fondazione Policlinico Universitario A Gemelli. Roma IRCCS  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Marasca","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences Section of Hematology University of Modena and Reggio Emilia  Modena Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monia","family":"Marchetti","sequence":"additional","affiliation":[{"name":"Oncology Unit Cardinal Massaia Hospital  Asti Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca R.","family":"Mauro","sequence":"additional","affiliation":[{"name":"Department of Translational and Precision Medicine Hematology \u2018Sapienza\u2019 University  Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Crea","sequence":"additional","affiliation":[{"name":"GIMEMA Foundation  Rome 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