{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:52:38Z","timestamp":1792036358356,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","award":["HONORS award"],"award-info":[{"award-number":["HONORS award"]}],"id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007043","name":"Lymphoma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>National Comprehensive Cancer Network guidelines recommend radiation therapy (RT) for localized indolent non\u2010Hodgkin lymphomas (iNHL). Many referring physicians avoid RT to the head and neck (HN) due to fears of toxicity. Very low\u2010dose radiation (4\u00a0Gy) for select patients produces sustained local control and recently gained popularity. We compared early and late toxicities of standard 24\u201330\u00a0Gy to 4\u00a0Gy in patients with HN iNHL. We retrospectively analyzed 266 consecutive patients with HN iNHL receiving RT from 1994 to 2017. Patient characteristics, outcomes, and toxicities were collected from medical records. Early (\u22642 months post\u2010RT) and late (&gt;2 months post\u2010RT) toxicities were graded per Common Terminology Criteria for Adverse Events version 4. Grades 1\u20132 were defined as \u201clow\u2010grade\u201d and 3\u20134 \u201chigh\u2010grade.\u201d Toxicity incidence was compared between 4 and\u00a0&gt;4\u00a0Gy, grouped by treated site (orbit, nonorbital head, neck, skin) and early versus late. Median follow\u2010up was 23 months (2\u2013145) and 68 months (2\u2013256) for 4Gy and &gt;4\u00a0Gy cohorts, respectively. Median dose for the &gt;4\u00a0Gy cohort was 30\u00a0Gy (10.5\u201354\u00a0Gy). Early and late toxicity incidences were lower in the 4\u00a0Gy cohort compared to &gt;4\u00a0Gy across all RT\u2010sites: early toxicity, orbit, 42% versus 96%; nonorbital head, 24% versus 96%; neck, 22% versus 94%; skin, 31% versus 87%; late toxicity, orbit, 20% versus 71%; nonorbital head, 6% versus 66%; neck, 6% versus 57%; skin, 0% versus 46% (4\u00a0Gy vs. &gt;4\u00a0Gy, respectively). Toxicities among both cohorts were largely low\u2010grade. High\u2010grade early and late toxicities did not occur in the 4\u00a0Gy cohort. There was 1 high\u2010grade early toxicity (Grade 3 dry mouth) and 17 high\u2010grade late toxicities (Grade 3 cataracts) in the &gt;4\u00a0Gy cohort. RT to HN for iNHL is associated with minimal short\u2010 and long\u2010term toxicity and excellent local control among 4\u00a0Gy and &gt;4\u00a0Gy treatments. In this setting, \u201ctoxicity\u201d concerns should not deter oncologists from potentially curative RT. In select patients where toxicity remains a concern, very low dose 4\u00a0Gy could be considered.<\/jats:p>","DOI":"10.1002\/hon.2865","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T20:35:00Z","timestamp":1616013300000},"page":"304-312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Low grade, indolent lymphomas of the head and neck: Comparative toxicity of standard versus very low dose radiation therapy"],"prefix":"10.1002","volume":"39","author":[{"given":"Monica","family":"Chelius","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Department of Radiation Oncology University of Pennsylvania  Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY USA"},{"name":"Department of Radiation Oncology University of California San Francisco  San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Hajj","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Imber","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Memorial Sloan Kettering Cancer Center  New York NY 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