{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:34:40Z","timestamp":1784810080483,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The AETHERA trial reported an increased progression\u2010free survival (PFS) when brentuximab vedotin (BV) was used as maintenance therapy in high\u2010risk Hodgkin lymphoma (HL) after autologous stem cell transplantation (ASCT). Thus, we aimed to determine the impact and safety of BV as maintenance after ASCT in real\u2010world patients. Seventy\u2010five patients with relapsed\/refractory HL started on BV consolidation therapy after ASCT due to high risk of relapse, between January 2016 and July 2019, from 25 institutions, were included in the study. The median follow\u2010up time was 26 months. The most common high\u2010risk features were primary refractory or relapsed disease &lt;12 months (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a061), lack of complete response (CR) to the last salvage regimen (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a051), and having had at least two salvage regimens (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a029). At the time of analysis, 42 patients completed consolidation courses, and BV was discontinued in 33 patients. Fifty patients had an ongoing response (CR in 41, PR in 6, and SD in 3 patients), 25 had progressed. Ten died in the follow\u2010up, eight with progressive disease and two due to infection while in CR. The 2\u2010year PFS and OS rates were 67.75% (95% confidence interval [CI]: 0.55\u20130.77) and 87.61% (95% CI: 0.76\u20130.94), respectively. Seventeen patients (23%) received BV in the pre\u2010ASCT treatment lines, and there was no survival difference between the BV\u2010na\u00efve and BV\u2010exposed groups. The most common adverse events were neutropenia (27%) and peripheral neuropathy (21%). Sixteen patients (21.3%) experienced grade 3 or 4 toxicity. BV was discontinued due to adverse event in 12 patients. Consolidation with BV after ASCT can achieve a 2\u2010year PFS of 67.75% (95% CI: 0.55\u20130.75) with an acceptable toxicity profile.\n                  <\/jats:p>","DOI":"10.1002\/hon.2897","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T15:49:10Z","timestamp":1624636150000},"page":"498-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Brentuximab vedotin consolidation therapy after autologous stem\u2010cell transplantation in patients with high\u2010risk Hodgkin lymphoma: Multicenter retrospective study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6759-1939","authenticated-orcid":false,"given":"Olga Meltem","family":"Akay","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Division of Hematology Ko\u00e7 University Medical Faculty  Istanbul 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Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2035-9462","authenticated-orcid":false,"given":"Leylagul","family":"Kaynar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology Erciyes University Medical Faculty  Kayseri Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orhan","family":"Ayyildiz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology Dicle University Medical Faculty  Diyarbak\u0131r Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3020-850X","authenticated-orcid":false,"given":"Ipek","family":"Yonal Hindilerden","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology Istanbul Medical Faculty Istanbul University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Sami","family":"Goksoy","sequence":"additional","affiliation":[{"name":"Depatment of Hematology Yeniyuzy\u0131l University Gaziosmanpa\u015fa Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-9424","authenticated-orcid":false,"given":"Sebnem","family":"Izmir Guner","sequence":"additional","affiliation":[{"name":"Depatment of Hematology Memorial \u015ei\u015fli Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5522-8342","authenticated-orcid":false,"given":"Ahmet Kursad","family":"Gunes","sequence":"additional","affiliation":[{"name":"Depatment of Hematology Mehmet Akif \u0130nan Hospital  \u015eanl\u0131urfa Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Division of Hematology Karadeniz Technical University  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and High\u2010throughput sequencing (HTS)\u2010Based response assessment after brentuximab vedotin (BV) plus ifosfamide, carboplatin, and etoposide (ICE) for relapsed\/refractory (Rel\/Ref) classical Hodgkin lymphoma (cHL): updated results of a phase I\/II trial","author":"Cassaday RD","year":"2017","journal-title":"2017 American Society of Hematology 58th Annual Meeting\u00a0& Exposition, San Diego, CA"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30426-1"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq211"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708984"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_9_20_1","volume-title":"Common Terminology Criteria for Adverse Events (CTCAE)","author":"US Department_of_Health and Human 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