{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:41:55Z","timestamp":1774464115191,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T00:00:00Z","timestamp":1625443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ruxolitinib, a potent Janus kinase 1\/2 inhibitor, has demonstrated durable improvements in patients with myelofibrosis. In this analysis of the Phase 3b JUMP study, which included patients aged \u226518 years with a diagnosis of primary or secondary myelofibrosis, we assessed the safety and efficacy of ruxolitinib in patients stratified by Dynamic International Prognostic Scoring System (DIPSS) risk categories. Baseline characteristic data were available to assess DIPSS status for 1844 of the 2233 enrolled patients; 60, 835, 755, and 194 in the low\u2010, intermediate (Int)\u20101\u2010, Int\u20102\u2010, and high\u2010risk groups, respectively. Ruxolitinib was generally well tolerated across all risk groups, with an adverse\u2010event (AE) profile consistent with previous reports. The most common hematologic AEs were thrombocytopenia and anemia, with highest rates of Grade \u22653 events in high\u2010risk patients. Approximately, 73% of patients experienced \u226550% reductions in palpable spleen length at any point in the \u226424\u2010month treatment period, with highest rates in lower\u2010risk categories (low, 82.1%; Int\u20101, 79.3%; Int\u20102, 67.1%; high risk, 61.6%). Median time to spleen length reduction was 5.1 weeks and was shortest in lower\u2010risk patients. Across measures, 40%\u201357% of patients showed clinically meaningful symptom improvements, which were observed from 4 weeks after treatment initiation and maintained throughout the study. Overall survival (OS) was 92% at Week 72 and 75% at Week 240 (4.6 years). Median OS was longer for Int\u20102\u2010risk than high\u2010risk patients (253.6 vs. 147.3 weeks), but not evaluable in low\u2010\/Int\u20101\u2010risk patients. By Week 240, progression\u2010free survival (PFS) and leukemia\u2010free survival (LFS) rates were higher in lower\u2010risk patients (PFS: low, 90%; Int\u20101, 82%; Int\u20102, 46%; high risk, 15%; LFS: low, 92%; Int\u20101, 86%; Int\u20102, 58%; high risk, 19%). Clinical benefit was seen across risk groups, with more rapid improvements in lower risk patients. Overall, this analysis indicates that ruxolitinib benefits lower\u2010risk DIPSS patients in addition to higher risk.<\/jats:p>","DOI":"10.1002\/hon.2898","type":"journal-article","created":{"date-parts":[[2021,7,5]],"date-time":"2021-07-05T09:47:34Z","timestamp":1625478454000},"page":"558-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparing the safety and efficacy of ruxolitinib in patients with Dynamic International Prognostic Scoring System low\u2010, intermediate\u20101\u2010, intermediate\u20102\u2010, and high\u2010risk myelofibrosis in JUMP, a Phase 3b, expanded\u2010access study"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-5289","authenticated-orcid":false,"given":"Francesco","family":"Passamonti","sequence":"first","affiliation":[{"name":"University of Insubria  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Martino","sequence":"additional","affiliation":[{"name":"Azienda Ospedaliera Bianchi\u2010Melacrino\u2010Morelli  Reggio Calabria Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda","family":"Foltz","sequence":"additional","affiliation":[{"name":"St Paul's Hospital University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrey","family":"Zaritskey","sequence":"additional","affiliation":[{"name":"Federal Almazov Medical Research Center of the Russian Ministry of Health  St Petersburg Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haifa Kathrin","family":"Al\u2010Ali","sequence":"additional","affiliation":[{"name":"University Hospital of Halle  Halle (Saale) Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato","family":"Tavares","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goiania  Goi\u00e2nia Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Maffioli","sequence":"additional","affiliation":[{"name":"Ospedale di Circolo, ASST Sette Laghi  Varese Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pia","family":"Raanani","sequence":"additional","affiliation":[{"name":"Rabin Medical Center Petah Tikva and Sackler School of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Miguel Servet University Hospital and Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER)  Zaragoza Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Griesshammer","sequence":"additional","affiliation":[{"name":"Johannes Wesling Clinic, University of Bochum  Minden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1809-284X","authenticated-orcid":false,"given":"Paola","family":"Guglielmelli","sequence":"additional","affiliation":[{"name":"CRIMM Center for Research and Innovation of Myeloproliferative Neoplasms AOU Careggi University of Florence  Florence Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Bouard","sequence":"additional","affiliation":[{"name":"Novartis Pharma  Rueil\u2010Malmaison France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carole","family":"Paley","sequence":"additional","affiliation":[{"name":"Novartis Pharma  East Hanover New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjan","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Novartis Healthcare Pvt., Ltd.  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