{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:04:56Z","timestamp":1761059096749},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":9071,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphocytes from 48 patients with B\u2010cell chronic lymphocytic leukemia (B\u2010CLL) and allied disorders were examined with a panel of monoclonal antibodies and conventional surface marker techniques. Surface immunoglobulin (SIg) and 1a\u2010like antigen were regularly present on B\u2010CLL cells. In addition, 24 of 32 specimens reacted with OKT1, a monoclonal antibody which detects both peripheral and thymic T cells, but reactivity was not observed with anti\u2010T\u2010cell monoclonal antibodies of more restricted specificity (OKT3, OKT4, OKT6, OKT8 or OKT11). Eighteen of 20 samples in which only SIgM was detected were OKT1 \u2013positive, while all 4 with only SIgG were OKT1\u2014negative. Cells from patients with hairy cell leukemia were unreactive with OKT1, but resembled B\u2010CLL lymphocytes in the presence of clonal SIg and 1a\u2010like antigen. Neoplastic plasma cells lacked 1a\u2010like antigen and frequently SIg (2 of 5), but cytoplasmic immunoglobulin was present, cells reacted with OKT 10 (replicating lymphoid cells) and 2 of 5 with OKT9 (transferrin receptor) as well. Cutaneous T\u2010cell lymphoma samples were reactive with the anti\u2010T\u2010cell monoclonal antibodies OKT1, OKT3 and OKT4 even when the sheep cell receptor could not be detected. Monoclonal antibodies can provide more certain diagnosis and superior resolution of cell lineage in these disorders than is possible by morphology alone.<\/jats:p>","DOI":"10.1002\/hon.2900010104","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T12:51:18Z","timestamp":1278679878000},"page":"13-19","source":"Crossref","is-referenced-by-count":13,"title":["Monoclonal antibody studies in B\u2010cell chronic lymphocytic leukemia and allied disorders"],"prefix":"10.1002","volume":"1","author":[{"given":"Alan C.","family":"Aisenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara M.","family":"Wilkes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198102053040606"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1182\/blood.V48.5.707.707","article-title":"Lymphosarcoma cell leukemia: the contribution of cell surface study to diagnosis","volume":"48","author":"Aisenberg A. C.","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.4.1126"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V58.4.818.818","article-title":"Chronic T\u2010cell lymphocytosis with neutropenia: Report of a case studied with monoclonal antibody","volume":"58","author":"Aisenberg A. C.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90482-X"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.3.526.526"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.152.1.229"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4049\/jimmunol.127.3.1256","article-title":"Monoclonal antibody OKT9 recognizes the receptor for transferrin on acute lymphocytic leukemia cells","volume":"127","author":"Goding J. W.","year":"1981","journal-title":"J. Immunol."},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.4049\/jimmunol.120.5.1480","article-title":"Patterns of expression of human \u20181a\u2010like\u2019 antigens during the terminal stages of B cell development","volume":"120","author":"Halper J. S.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198105283042202"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood.V59.1.52.52","article-title":"Cell markers in hairy\u2010cell leukemia studied in cells from 51 patients","volume":"59","author":"Jansen J.","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1182\/blood.V57.2.261.261","article-title":"Cutaneous T cell lymphoma: Characterization by monoclonal antibodies","volume":"57","author":"Kung P. C.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4049\/jimmunol.125.1.293","article-title":"Two populations of 1a\u2010like molecules on a human B cell line","volume":"125","author":"Lampson L. A.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81092-3_4"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:8 <1488::AID-CNCR2820340822>3.0.CO;2-C"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.3.1588"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.4049\/jimmunol.125.2.725","article-title":"Human T\u2010cell antigens defined by monoclonal antibodies: The 65 000\u2010Dalton antigen of T\u2010cells (T65) is also found on chronic lymphocytic leukemia cells bearing surface immunoglobulin","volume":"125","author":"Royston I.","year":"1980","journal-title":"J. Immunol."},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1182\/blood.V59.2.207.207","article-title":"Immunologic classification of lymphocytic leukemias based on monoclonal antibody\u2010defined cell surface antigens","volume":"59","author":"Schroff R. W.","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_21_1","first-page":"99","volume-title":"Leukemia Markers.","author":"Stein H.","year":"1981"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.151.6.1539"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900010104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900010104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:30:13Z","timestamp":1697761813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900010104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/hon.2900010104"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900010104","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}