{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:38:48Z","timestamp":1772793528161,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":9071,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expression of endogenous retrovirus genes and two different cellular oncogenes (<jats:italic>c\u2010onc<\/jats:italic> genes) was examined at the transcriptional level in a variety of normal and lymphoma\/leukemia tissues of the domestic cat. The two oncogenes, <jats:italic>c\u2010myb<\/jats:italic>(related to avian myeloblastosis virus) and <jats:italic>c\u2010myc<\/jats:italic>(related to avian myelocytomatosis virus) were selected for their association with the induction of hematopoietic malignancies, when present in the transforming retroviruses. Tissue\u2010specific expression of endogenous feline leukemia virus (FeLV)\u2010related genes was detected in cellular subpopulations of the cat placenta by <jats:italic>in situ<\/jats:italic> method of hybridization. Gel blotting analysis of placental poly(A)\u2010selected RNA revealed that the FeLV\u2010related RNA species were primarily subgenomic, representing the <jats:italic>env<\/jats:italic> gene region of the endogenous provirus elements. Like the endogenous retrovirus genes, <jats:italic>c\u2010myb<\/jats:italic> and <jats:italic>c\u2010myc<\/jats:italic> loci of the cat genomic DNA were also transcribed at differential levels in normal tissues of the cat. Dot\u2010blot hybridization analysis showed that the expression of these two oncogenes was linked to growth and development as it varied with the gestational age of the fetus and from fetal to adult tissues. Among the major hematopoietic organs, spleen and bone marrow contained both <jats:italic>c\u2010myb<\/jats:italic> and <jats:italic>c\u2010myc<\/jats:italic> transcripts, while thymus preferentially expressed the <jats:italic>c\u2010myb<\/jats:italic> gene. In contrast to the low level <jats:italic>of c\u2010myc<\/jats:italic> expression in fetal thymus tissues, enhanced <jats:italic>c\u2010myc<\/jats:italic> expression was detected in all five thymomas tested and also in several other neoplasms including two granulocytic leukemias. The feline <jats:italic>c\u2010myb<\/jats:italic> gene was not very active in granulocytic leukemias or in three of the five thymomas. RNA gel blotting analysis of poly(A)\u2010selected RNA of a thymoma and its lymph node metastasis showed identical pattern of <jats:italic>c\u2010myc<\/jats:italic> transcripts.<\/jats:p>","DOI":"10.1002\/hon.2900010108","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T12:52:46Z","timestamp":1278679966000},"page":"61-75","source":"Crossref","is-referenced-by-count":32,"title":["Characterization of the expression of cellular retrovirus genes and oncogenes in feline cells"],"prefix":"10.1002","volume":"1","author":[{"given":"Michael P.","family":"Busch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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