{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T05:34:46Z","timestamp":1697780086515},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":9071,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The therapeutic response and survival after the onset of the acute crisis in 64 patients with Ph'\u2010positive chronic myeloid leukemia (CML) were correlated with the chromosomal findings during the course of the acute phase. The patients were divided into three groups on the basis of the chromosome findings in the bone marrow, blood, and spleen: i.e. those with only a Ph<jats:sup>1<\/jats:sup> (PP), those having two types of clones, Le. one clone with only a Ph<jats:sup>1<\/jats:sup> and another with additional karyotypic changes (AP), and those with only abnormal clones containing karyotypic abnormalities in addition to the Ph<jats:sup>1<\/jats:sup> (AA). The number of patients in each group was: 22 in PP, 25 in AP and 17 in AA. The results were as follows: (1) The percentage of patients with a good therapeutic response was 77 per cent (17\/22) in PP, 60 per cent (15\/25) in AP and 29 per cent (5\/17) in AA and 2). The median survival after the onset of the acute crisis was 148 days (4\u20139 months) in PP, 183 days (6T months) in AP and 53 days (1\u20138 months) in AA. Statistically, there was a significant difference between the AA and the other two groups (<jats:italic>P<\/jats:italic> &lt; 0.001). Our observations suggest that the lack of a clone with only a Ph<jats:sup>1<\/jats:sup> during the course of the acute phase (AA) indicates an unfavourable response and a poor prognosis after the onset of the acute crisis in CML.<\/jats:p>","DOI":"10.1002\/hon.2900010109","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T13:09:56Z","timestamp":1278680996000},"page":"77-83","source":"Crossref","is-referenced-by-count":7,"title":["Chromosomes and causation of human cancer and leukemia. IL. Therapeutic and prognostic value of chromosomal findings during acute phase in PHI\u2010positive chronic myeloid leukemia"],"prefix":"10.1002","volume":"1","author":[{"given":"Naoki","family":"Sadamori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German A.","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avery A.","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207833"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207679"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830040311"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1182\/blood.V54.4.818.818","article-title":"Correlation between prognosis and bone marrow chromosomal patterns in children with acute non\u2010lymphocytic leukemia: similarities and differences compared to adults","volume":"54","author":"Benedict W. 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M.","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01102.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01103.x"},{"key":"e_1_2_1_12_1","volume-title":"Primer of Biostatistics.","author":"Glantz S. A.","year":"1981"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197809212991201"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(78)90030-9"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1977.tb01506.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207922"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(77)90062-5"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00273096"},{"key":"e_1_2_1_19_1","first-page":"313","article-title":"Chromosomes and causation of human cancer and leukemia. XV. Prognostic value of chromosomal findings in Ph'\u2010positive CML","volume":"36","author":"Sakurai M.","year":"1976","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1182\/blood.V41.1.93.93","article-title":"Prognosis of acute myeloblastic leukemia: chromosome correlation","volume":"41","author":"Sakurai M.","year":"1973","journal-title":"Blood"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197406)33:6<1548::AID-CNCR2820330612>3.0.CO;2-M"},{"key":"e_1_2_1_22_1","volume-title":"The Chromosomes in Human Cancer and Leukemia.","author":"Sandberg A. 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