{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T15:27:38Z","timestamp":1697902058956},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":8890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>After decades of work, a retrovirus of true human origin has been isolated first from a U.S. adult case of T\u2010cell lymphoma and then from cases from various regions of the world. This virus, named HTLV\u2010I, is strongly associated with a malignant leukemia\u2010lymphoma of mature T\u2010cells. This disease was first clinically characterized in Japan but subsequently found to cluster in the Caribbean region, areas of the U.S. and in other countries. This retrovirus\u2010associated malignancy has an adult onset and usually a rapidly fatal course. Lymphadenopathy, hepatosphenomegally, cutaneous infiltration and hypercalcemia are found. HTLV\u2010I has been characterized in detail and shown to be an exogenous retrovirus.<\/jats:p><jats:p>HTLV\u2010I infection is detected in normal populations and is endemic in restricted areas of Japan, the Caribbean, South America, and the U.S. Cases of ATL tend to cluster in these areas. Future studies will focus on learning (1) how HTLV\u2010I is transmitted from individual to individual; (2) the nature of the mechanism by which HTLV\u2010I transforms T\u2010cells; (3) whether we can use probes from HTLV\u2010I to detect other (related) retroviruses in other human neoplasms.<\/jats:p>","DOI":"10.1002\/hon.2900010302","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T13:15:30Z","timestamp":1278681330000},"page":"193-204","source":"Crossref","is-referenced-by-count":6,"title":["Retroviruses in human leukemia"],"prefix":"10.1002","volume":"1","author":[{"given":"Douglas W.","family":"Blayney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Blattner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine S.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1089","article-title":"Natural mode of transmission of the bovine leukemia virus: role of blood sucking insects","volume":"39","author":"Bech\u2010Nielsen S.","year":"1978","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910300302"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90056-9"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-2-144"},{"key":"e_1_2_1_6_1","unstructured":"Blayney D. W. Blattner W. A. Robert\u2010Guroff M. Jaffe E. S. Fisher R. I. Bunn P. A. Patton M. G. Rarick H. R. Gallo R. C.(1983b). The human T\u2010cell leukemia\/lymphoma virus (HTLV) In the southeastern United States.JAMA in press."},{"key":"e_1_2_1_7_1","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood.V62.2.401.401","article-title":"The human T\u2010cell leukemia\/lymphoma virus (HTLV) associated with American adult T\u2010cell leukemia\/lymphoma (ATL).","volume":"62","author":"Blayney D. W.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.118.7.461"},{"key":"e_1_2_1_9_1","first-page":"231","volume-title":"Viral Oncology","author":"Burny A.","year":"1980"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7778"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92200-0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(80)90028-4"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1128\/jvi.40.2.605-609.1981","article-title":"Experiments with cloned complete tumor\u2010derived bovine leukemia virus information prove that the virus is totally exogenous to its target animal species","volume":"40","author":"Deschamp J.","year":"1981","journal-title":"J. Virol."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60973-2"},{"key":"e_1_2_1_15_1","first-page":"893","article-title":"Studies on the relationship between infection with bovine C\u2010type virus, leukemia and persistent lymphocytes in cattle","volume":"34","author":"Ferrer J. F.","year":"1974","journal-title":"Cancer Res."},{"key":"e_1_2_1_16_1","first-page":"1","article-title":"Bovine lymphosarcoma","volume":"24","author":"Ferrer J. F.","year":"1980","journal-title":"Advances in Veterinary Science and Comparative Medicine"},{"key":"e_1_2_1_17_1","first-page":"4738","article-title":"Kyoto workshop on some specific recent advances in human tumor virology","volume":"41","author":"Gallo R. C.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.18.5680"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1182\/blood.V60.3.545.545","article-title":"Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis","volume":"60","author":"Gallo R. C.","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_20_1","article-title":"Association of the human type C retrovirus with a subset of adult T\u2010cell cancers","volume":"43","author":"Gallo R. C.","year":"1983","journal-title":"Cancer Res."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-29-3-305"},{"key":"e_1_2_1_22_1","volume-title":"Oncogenic Viruses.","author":"Gross L.","year":"1970"},{"key":"e_1_2_1_23_1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/ajcp\/75.2.149","article-title":"Hypercalcemia associated with T\u2010cell lymphoma\u2010leukemia","volume":"75","author":"Grossman B.","year":"1981","journal-title":"American Journal of Clinical Pathology"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/303253a0"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/244266a0"},{"key":"e_1_2_1_26_1","first-page":"677","volume-title":"Viruses and Naturally Occurring Cancer, VII Cold Spring Harbour Conference on Cell Proliferation","author":"Hardy W. D.","year":"1980"},{"key":"e_1_2_1_27_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V58.3.645.645","article-title":"Surface phenotype of Japanese adult T\u2010cell leukemia cells characterized by monoclonal anti\u2010bodies","volume":"58","author":"Hattori T.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.2054"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)91885-8"},{"key":"e_1_2_1_31_1","first-page":"566","article-title":"Leukemia in the cat","volume":"202","author":"Jarrett W. F.","year":"1964","journal-title":"Nature"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92013-X"},{"key":"e_1_2_1_33_1","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1128\/jvi.38.3.906-915.1981","article-title":"Immunological properties of a type\u2010C retrovirus isolated from cultured human T\u2010lymphom cells and comparison to other mammalian retroviruses","volume":"38","author":"Kalyanaraman V. S.","year":"1981","journal-title":"J. Virol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6981847"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","unstructured":"Kettmann R. Deschamps J. Cleuter Y. Couez D. Burny A. Marbaix G.(1983). Leukemogenesis by bovine leukemia virus: Proviral DNA integration and lack of RNA expression of viral long terminal repeat and 3 proximate cellular sequences.Proc. Natl. Acad. Sci. U.S.A. in press.","DOI":"10.1073\/pnas.79.8.2465"},{"key":"e_1_2_1_36_1","first-page":"15","article-title":"Statistical analysis of immunologic, clinical and histopathologic data on lymphoid malignancies in Japan","volume":"11","author":"Kikuchi K.","year":"1981","journal-title":"Jpn. J. Clin. Oncol."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821015)50:8<1554::AID-CNCR2820500815>3.0.CO;2-Q"},{"key":"e_1_2_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(79)90044-8"},{"key":"e_1_2_1_39_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood.V57.1.13.13","article-title":"Purification and characterization of a human T\u2010lymphocyte derived granulocyte\u2010macrophage colony stimulating factor","volume":"57","author":"Lusis A. J.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.6.1574"},{"key":"e_1_2_1_41_1","doi-asserted-by":"crossref","unstructured":"Manzari V. Wong\u2010Staal F. Franchini G. Colombini S. Gelmann E. P. Oroszlan S. Staal S. P. Gallo R. C.(1983b). Human T\u2010cell leukemia\u2010lymphoma virus HTLV: Molecular cloning of an integrated defective provirus and flanking cellular sequences.Proc. Natl. Acad. Sci. U.S.A. in press.","DOI":"10.1073\/pnas.80.6.1574"},{"key":"e_1_2_1_42_1","first-page":"202","volume":"22","author":"Marshak R. R.","year":"1962","journal-title":"Cancer Res."},{"key":"e_1_2_1_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.10.6134"},{"key":"e_1_2_1_44_1","first-page":"155","article-title":"A novel T\u2010cell line derived from adult T\u2010cell leukemia","volume":"71","author":"Miyoshi I.","year":"1980","journal-title":"Gann"},{"key":"e_1_2_1_45_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.181845"},{"key":"e_1_2_1_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90847-1"},{"key":"e_1_2_1_47_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.4.1291"},{"key":"e_1_2_1_48_1","first-page":"873","article-title":"Evidence for the replication of bovine leukemia virus in the B\u2010lymphocytes","volume":"38","author":"Paul P. S.","year":"1977","journal-title":"Am. J. Vet. Res."},{"key":"e_1_2_1_49_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.11.6815"},{"key":"e_1_2_1_50_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/294268a0"},{"key":"e_1_2_1_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/300063a0"},{"key":"e_1_2_1_53_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6600519"},{"key":"e_1_2_1_54_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.2.333"},{"key":"e_1_2_1_55_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.3.1887"},{"key":"e_1_2_1_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90642-5"},{"key":"e_1_2_1_57_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.154.6.1957"},{"key":"e_1_2_1_58_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6760397"},{"key":"e_1_2_1_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.1.248"},{"key":"e_1_2_1_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_61_1","unstructured":"Saxinger C. Gallo R. C.(1983). Application of the indirect ELISA microtest to the detection and surveillance of human T\u2010cell leukemia\u2010lymphoma virus (HTLV).Lab. Investigation in press."},{"key":"e_1_2_1_62_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-88-3-323"},{"key":"e_1_2_1_63_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198204223061619"},{"key":"e_1_2_1_64_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-78-3-365"},{"key":"e_1_2_1_65_1","first-page":"684","article-title":"A hypothesis on the etiology of adult T\u2010cell lymphoma","volume":"72","author":"Tajima K.","year":"1981","journal-title":"Gann"},{"key":"e_1_2_1_66_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T\u2010cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uehiyama T.","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)90200-8"},{"key":"e_1_2_1_68_1","doi-asserted-by":"crossref","unstructured":"Waldmann T. A. Broder S. Greene W. C. Sarin P. S. Saxinger C. Blayney D. W. Blattner W. A. Goldman C. K. Frost K. Sharrow S. Depper J. M. Leonard W. L. Uehiyama T. K. Gallo R. C.(1983). A functional and phenotypic comparison of human T\u2010leukemia\/lymphoma (HTLV) positive adult T\u2010cell leukemia with HTLV negative sezary leukemia and their distinction using anti\u2010TAC a monoclonal antibody identifying the human receptor for T\u2010cell growth factor submitted.","DOI":"10.1172\/JCI111379"},{"key":"e_1_2_1_69_1","first-page":"381","volume-title":"Feline Leukemia virus","author":"Wong\u2010Staal F.","year":"1980"},{"key":"e_1_2_1_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/302626a0"},{"key":"e_1_2_1_71_1","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1182\/blood.V61.1.192.192","article-title":"Phenotypic and functional analysis of leukemica cells from 16 patients with adult T\u2010cell leukemia lymphoma","volume":"61","author":"Yamada Y.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_72_1","doi-asserted-by":"publisher","DOI":"10.1515\/znc-1982-7-828"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900010302","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900010302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T04:50:51Z","timestamp":1697691051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900010302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,7]]}},"alternative-id":["10.1002\/hon.2900010302"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900010302","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,7]]}}}