{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:21:31Z","timestamp":1698078091119},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":8890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>On the basis of the 6 cases reported here and scattered published cases, the existence of a childhood chronic immunoblastic lymphadenopathy syndrome is proposed. It is characterized by the following features:<\/jats:p><jats:p>A systemic immunoblastic proliferation with varying degrees of maturation resembling the B lymphocyte hyperimmune disorder observed in angioimmunoblastic lymphadenopathy but with no deposits of interstitial amorphous material or vascular proliferation.<\/jats:p><jats:p>Disseminated superficial and deep lymphadenopathy.<\/jats:p><jats:p>Chronic, pronounced splenomegaly.<\/jats:p><jats:p>A constant thrombocytopenia.<\/jats:p><jats:p>A polyclonal hypergammaglobulinemia, with markedly elevated antibody titers to various agents. An early onset and a course of several years (up to 20), interrupted in half the cases by the occurrence of a virus\u2010associated (EBV, Papova) neoplastic process or a fatal viral infection.<\/jats:p><jats:p>Low natural killer (NK) cell activity in 2 cases.<\/jats:p>","DOI":"10.1002\/hon.2900010305","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T13:16:20Z","timestamp":1278681380000},"page":"227-242","source":"Crossref","is-referenced-by-count":7,"title":["Long lasting lymphadenopathy in childhood as an expression of a severe hyperimmune B lymphocyte disorder"],"prefix":"10.1002","volume":"1","author":[{"given":"C.","family":"Nezelof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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Invest."},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4049\/jimmunol.120.3.796","article-title":"Natural killing in immunodeficient patients","volume":"120","author":"Koren H. S.","year":"1978","journal-title":"J. Immunol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)90587-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830100405"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501022920101"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90407-8"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197907)44:1<171::AID-CNCR2820440129>3.0.CO;2-E"},{"key":"e_1_2_1_24_1","first-page":"533","article-title":"Panh\u00e9mopathie autoimmune avec hypoerplasie lymphoide chez un enfant","volume":"34","author":"Peraldi M.","year":"1977","journal-title":"Arch. Fran\u00e7. Ped."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(81)80162-1"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1106350"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/284553a0"},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.4049\/jimmunol.123.5.2150","article-title":"Inhibition of the in vitro outgrowth of Epstein\u2010Barr virus infected cells by TG lymphocytes","volume":"123","author":"Shope T. C.","year":"1979","journal-title":"J. Immunol."},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92156-X"},{"key":"e_1_2_1_30_1","first-page":"473","volume-title":"Primary Immunodeficiencies","author":"Virelizier J. 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