{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T04:39:37Z","timestamp":1698035977916},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,2]],"date-time":"2007-11-02T00:00:00Z","timestamp":1193961600000},"content-version":"vor","delay-in-days":8890,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1983,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Using a sister chromatid differentiation technique, cell cycle study of stimulated lymphocytes of B\u2010Cell chronic lymphocytic leukemia (B\u2010CLL) revealed their cell cycle progression to be similar to that of normal lymphocytes stimulated by T\u2010cell and various polyclonal B\u2010cell activators (PBA). The chromosome constitutions of stimulated lymphocytes in 62 patients with B\u2010CLL were examined using PBA such as Epstein\u2010Barr virus (EBV) and lipopolysaccharide W from <jats:italic>E. coli<\/jats:italic> 055:B5 (LPS). Of the 20 patients with abnormal clones, 11 patients had trisomy 12; other less common abnormalities were trisomy 1, 6q\u2010, i(7q), 14q+, trisomy 16, trisomy 18, reciprocal translocations, and marker chromosomes of unknown origin. These findings indicate that trisomy 12 may be a unique and common karyotypic change in B\u2010CLL. The fact that 3 out of 4 patients with marker chromosomes showed stage IV disease may indicate that a clone with a marker is a predictor of an unfavourable prognosis. The near correlation between trisomy 12 and K chains existed (0.05&lt;<jats:italic>p<\/jats:italic>&lt;0.10). Trisomy 12 was seen in all 5 patients with monoclonal paraprotein.<\/jats:p>","DOI":"10.1002\/hon.2900010306","type":"journal-article","created":{"date-parts":[[2010,7,9]],"date-time":"2010-07-09T13:16:30Z","timestamp":1278681390000},"page":"243-250","source":"Crossref","is-referenced-by-count":8,"title":["Chromosome studies in stimulated lymphocytes of B\u2010Cell chronic lymphocytic leukemias"],"prefix":"10.1002","volume":"1","author":[{"given":"Naoki","family":"Sadamori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tin","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Minowada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avery A.","family":"Sandberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,11,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90066-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(79)90020-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90071-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01103.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90082-6"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V56.4.640.640"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Han T. Sadamori N. Takeuchi J. Ozer H. Henderson E. S. Fitzpatrik J. Sandberg A. A.(1983). Clonal chromosome abnormalities in patients with Waldenstr\u00f6m's and CLL\u2010associated macro\u2010globulinemia: significance of trisomy 12.Blood in press.","DOI":"10.1182\/blood.V62.3.525.525"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130034"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.12.3395"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/298474a0"},{"key":"e_1_2_1_12_1","volume-title":"Human Gene Mapping Conference VI","author":"Malcolm S.","year":"1981"},{"key":"e_1_2_1_13_1","first-page":"1169","article-title":"Sister chromatid exchange and cell cycle progression in cultured lymphocytes from patients with chronic lymphatic leukemia","volume":"62","author":"McDonald M. A.","year":"1979","journal-title":"J. Natl. 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