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Survival of the 782 (69\u20134 per cent) patients with low\u2010grade malignant NHL (lymphocytic lymphomas, predominantly B\u2010CLL, LP immunocytoma, centrocytic lymphoma, centroblastic\u2010centrocytic lymphoma) exceeded that of the 341 patients (30\u20132 per cent) with high\u2010grade malignant NHL (centroblastic, immunoblastic, lymphoblastic lymphomas). Prognosis was best in centroblastic\u2010centrocytic lymphoma and in B\u2010CLL and least favorable in immunoblastic and lymphoblastic lymphomas. Survival of LP immunocytoma and centrocytic lymphoma patients was intermediate after 2 to 2\u00b75 years of follow\u2010up. Corresponding to histopathology, pattern of survival curves of low\u2010grade malignant NHL (slow decline, no plateauing) differed from that of high\u2010grade malignant NHL (rapid decline, subsequent plateauing). Prognosis of B\u2010CLL was superior to that of LP immunocytoma. Stages I and II were more frequent in centroblastic\u2010centrocytic lymphoma (21 per cent) than in LP immunocytoma (2\u00b75 per cent) and centrocytic lymphoma (11 per cent). Ability of radiotherapy to induce stable complete remissions in stage III of centroblastic\u2010centrocytic lymphoma indicates prolonged restriction of lymphoma to the lymphatic system. In immunoblastic and centroblastic lymphomas, stages I and II were diagnosed in 34 and 38 per cent of cases, respectively, but only in stage I\/I<jats:sub>E<\/jats:sub> of centroblastic lymphoma prolonged remissions were achieved by radiotherapy. In advanced high\u2010grade malignant NHL marked improvement of prognosis was solely possible by induction of complete remissions whereas in corresponding low\u2010grade malignant lymphomas also partial remissions were prognostically relevant.<\/jats:p>","DOI":"10.1002\/hon.2900020306","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T10:39:39Z","timestamp":1358246379000},"page":"269-306","source":"Crossref","is-referenced-by-count":165,"title":["Clinical and prognostic relevance of the Kiel classification of non\u2010Hodgkin lymphomas results of a prospective multicenter study by the Kiel Lymphoma Study Group"],"prefix":"10.1002","volume":"2","author":[{"given":"G.","family":"Brittinger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bartels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Common","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"D\u00fchmke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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