{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:30:05Z","timestamp":1759581005823},"reference-count":71,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"vor","delay-in-days":10333,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1984,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The serum levels of beta 2\u2010microglobulin (\u03b2<jats:sub>2<\/jats:sub>m), which is the light chain moiety of the HLA (\u2010A, \u2010B, \u2010C) antigens, are increased in many of the haematological malignancies. In the lymphoproliferative disorders there is generally an association between serum \u03b2<jats:sub>2<\/jats:sub>m and estimates of tumour load. This relationship is especially close in myelomatosis, where serum \u03b2<jats:sub>2<\/jats:sub>m is a powerful prognostic indicator and can be used in stratification and monitoring. Increases in serum \u03b2<jats:sub>2<\/jats:sub>m are also frequent in the myeloproliferative disorders, notably in myelofibrosis, and in the myelodysplastic syndromes; particularly high levels are seen in chronic myelomonocytic leukaemia. In addition to suggested cellular sources of the \u03b2<jats:sub>2<\/jats:sub>m in these diseases\u2014malignant lymphoid cells and cells of the monocyte\u2010macrophage series\u2014the possibility that T lymphocyte sub\u2010sets could be important contributors to the increased \u03b2<jats:sub>2<\/jats:sub>m production is discussed.<\/jats:p>","DOI":"10.1002\/hon.2900020409","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T10:40:43Z","timestamp":1358246443000},"page":"391-401","source":"Crossref","is-referenced-by-count":31,"title":["Serum beta 2\u2010microglobulin in lymphoproliferative and myeloproliferative diseases"],"prefix":"10.1002","volume":"2","author":[{"given":"J. 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