{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T05:40:18Z","timestamp":1697866818482},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"vor","delay-in-days":7918,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1985,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty consecutive patients with acute lymphoblastic leukaemia (ALL) who received treatment at Christchurch Hospital between 1972 and 1982 were reviewed. Complete remission (CR) was achieved in 80 per cent with a median survival of 65 weeks. Eleven of 30 patients had one or more of the following features\u2014B cell ALL, a mediastinal mass, the Philadelphia chromosome (Ph<jats:sup>1<\/jats:sup>) and age 60 years or older at diagnosis. Although CR was obtained in 8 of these patients none survived three years. The remaining 19 patients were regarded as \u2018good risk\u2019 and treated by moderate intensity chemotherapy schedules. CR was obtained in 16 of these patients (84 per cent) and the estimated 5 year survival was 62 per cent with 6 patients remaining in remission from 5 to 9 years from diagnosis.<\/jats:p><jats:p>These results demonstrate the value of objective and reproducible clinical and laboratory findings in defining a subset of ALL patients which may not require high intensity chemotherapy schedules.<\/jats:p>","DOI":"10.1002\/hon.2900030310","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:20:32Z","timestamp":1171887632000},"page":"211-216","source":"Crossref","is-referenced-by-count":0,"title":["Adolescent and adult lymphoblastic leukaemia: Prognostic factors and response to treatment"],"prefix":"10.1002","volume":"3","author":[{"given":"G. G.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. N. J.","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Heaton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E. J.","family":"Beard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb00188.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02684.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1050::AID-CNCR2820350406>3.0.CO;2-F"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1182\/blood.V57.4.679.679","article-title":"Lymphoblastic lymphoma in adults: results of a pilot protocol","volume":"57","author":"Coleman N.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197603)37:3<1256::AID-CNCR2820370305>3.0.CO;2-R"},{"key":"e_1_2_1_7_1","first-page":"1185","article-title":"Combination chemotherapy: Rationale for schedule selection and use of agents with independent toxicities in phase I and II clinical trials","volume":"5","author":"Gottlieb J. A.","year":"1973","journal-title":"Transplantation Proc."},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1182\/blood.V64.1.38.38","article-title":"Intensified therapy in acute lymphoblastic and acute undifferentiated leukaemia in adults","volume":"64","author":"Hoelzer D.","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1182\/blood.V33.2.370.370","article-title":"Combination chemotherapy in lymphosarcoma and reticulum cell sarcoma","volume":"33","author":"Hoogstraten B.","year":"1969","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.71"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6107.199"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197903)43:3<1128::AID-CNCR2820430352>3.0.CO;2-Y"},{"key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1200\/JCO.1983.1.8.462","article-title":"Treatment of acute lymphoblastic leukaemia in adults; results of the L\u201010 and L\u201010M protocols","author":"Schauer P.","year":"1983","journal-title":"J. Clin. Oncol."},{"key":"e_1_2_1_15_1","first-page":"543","article-title":"Cyclophosphamide (NSC\u2010262711), vincristine (NSC\u201067574), cytosine arabinoside (NSC\u201063878) and prednisone (NSC\u201010023) combination chemotheraphy for acute leukaemia in adults","volume":"56","author":"Whitecar J. P.","year":"1972","journal-title":"Cancer Chemotherapy Reports"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970202"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198109243051305"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900030310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900030310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:54:51Z","timestamp":1697824491000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900030310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,7]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,7]]}},"alternative-id":["10.1002\/hon.2900030310"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900030310","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,7]]}}}