{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T05:27:11Z","timestamp":1736832431991,"version":"3.33.0"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"vor","delay-in-days":7553,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this communication we present the results of the study of the surface antigen expression of cells dispersed from 19 fresh lymph node biopsies. All cases subsequently received a histological diagnosis of T\u2010cell lymphoma (T\u2010NHL). The monoclonal antibody (Mab) panel employed for surface staining of viable cells contained reagents reactive with the sheep red blood cell receptor (OKT11) and T3\u2010receptor associated determinants (UCHT1, OKT3) and a range of surface antigens found on subsets of T\u2010cells. These antibodies are characterized according to their CD group as allocated by the First and Second Monoclonal Antibody Workshops. Cells were also stained with Mabs reactive with MHC class II subregion products. All 19 cases displayed marked heterogeneity for both pan\u2010T\u2010cell and T\u2010subset antigens. An observation which is significant in terms of the routine diagnosis of T\u2010NHL and with regard to the rational classification of node\u2010based tumours of T\u2010cell origin<\/jats:p><jats:p>Unlike resting peripheral blood T\u2010cells, MHC class I1 subregion products were expressed on most of the cases examined though Tu22, directed towards a monomorphic determinant of HLA\u2010DQ, stained fewer cells than other antibodies. Aberrant expression of MHC class I1 on lymphoma cells may reflect the activation of the tumour population.<\/jats:p>","DOI":"10.1002\/hon.2900040306","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:13:53Z","timestamp":1171887233000},"page":"219-226","source":"Crossref","is-referenced-by-count":14,"title":["Phenotypic heterogeneity displayed by T\u2010NON Hodgkin's lymphoma (T\u2010NHL) cells dispersed from diagnostic lymph node biopsies"],"prefix":"10.1002","volume":"4","author":[{"given":"D. B.","family":"Jones","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Wright","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Paul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1182\/blood.V61.3.469.469","article-title":"Monoclonal antibody studies in non\u2010Hodgkin's lymphoma","volume":"61","author":"Aisenberg A. C.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_3_1","first-page":"593","article-title":"Human lymphocyte markers defined by antibodies derived from somatic cell hybrids II. A hybridoma secreting antibody against an antigen expressed by human B\u2010 and null lymphocytes","volume":"40","author":"Beckman I. G. R.","year":"1980","journal-title":"Clin. Exp. Immunol."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91786-3"},{"key":"e_1_2_1_5_1","first-page":"33","article-title":"Subpopulations of normal and leukaemic human thymocytes: An analysis with the use of monoclonal antibodies","volume":"65","author":"Bradstock K. F.","year":"1980","journal-title":"J. Natl. Cancer. Inst."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/ajcp\/79.3.285","article-title":"Peripheral T\u2010cell lymphoma: A clinicopathological study of nine cases","volume":"79","author":"Brisbane J. U.","year":"1983","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_7_1","first-page":"607","article-title":"Current concepts in immunoregulatory T\u2010cell neoplasms","volume":"63","author":"Broder S.","year":"1979","journal-title":"Cancer Treat. Rep."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92127-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1984.tb00944.x"},{"key":"e_1_2_1_10_1","first-page":"245","article-title":"The immunologic characterisation of 95 nodal and extra\u2010nodal diffuse large cell lymphomas in 89 patients","volume":"115","author":"Doggett R. S.","year":"1984","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_11_1","first-page":"489","article-title":"Differential expression of HLA class II antigens on human fetal and adult lymphocytes and macrophages","volume":"55","author":"Edwards J. A.","year":"1985","journal-title":"Immunology"},{"key":"e_1_2_1_12_1","first-page":"406","article-title":"Classification of non\u2010Hodgkin's lymphoma","author":"Gerard\u2010Marchant R.","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_1_13_1","first-page":"4752","article-title":"Analysis of the clinical and biological significance of lymphoid phenotypes in acute leukaemia","volume":"41","author":"Greaves M. F.","year":"1981","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1984.250"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/83.3.279"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830121109"},{"key":"e_1_2_1_17_1","first-page":"283","article-title":"Anomalous expression of MHC class II antigens on human monocytes","volume":"2","author":"Guy K.","year":"1984","journal-title":"Dis. Markers"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01711721"},{"key":"e_1_2_1_19_1","first-page":"58","article-title":"Immunologic, pathologic and clinical analysis of peripheral T\u2010cell lymphomas","volume":"160","author":"Jaffe E. S.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_20_1","first-page":"187","article-title":"Human T\u2010cell malignancies: Correlative, clinical, histopathologic, immunologic and cytochemical analysis of 23 cases","volume":"106","author":"Knowles D. M.","year":"1982","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830120305"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1182\/blood.V57.2.261.261","article-title":"Cutaneous T\u2010cell lymphoma: Characteristics by monoclonal antibodies","volume":"57","author":"Kung P. C.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81092-3"},{"key":"e_1_2_1_24_1","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1182\/blood.V62.4.722.722","article-title":"A single monoclonal antibody identifies T\u2010cell lineage of childhood lympoid malignancies","volume":"62","author":"Link M.","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197410)34:8 <1488::AID-CNCR2820340822>3.0.CO;2-C"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)92791-6"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.154"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811215)48:12<2630::AID-CNCR2820481215>3.0.CO;2-P"},{"key":"e_1_2_1_29_1","first-page":"363","article-title":"Table of Workshop monoclonal antibodies and a synopsis of their principal characteristics","volume":"2","author":"Steel C. M.","year":"1984","journal-title":"Dis. Markers"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003001"},{"key":"e_1_2_1_31_1","first-page":"152","volume-title":"Hodgkin's and non\u2010Hodgkin's Lymphomas","author":"Stein R. S.","year":"1980"},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60456-X"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198509263131303"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197710)40:4<1604::AID-CNCR2820400433>3.0.CO;2-H"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80226-4"},{"key":"e_1_2_1_36_1","first-page":"73","article-title":"The identification and classification of non\u2010Hodgkin's lymphoma: A review","volume":"5","author":"Wright D. H.","year":"1982","journal-title":"Diagnost. Histopathol."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310605"},{"volume-title":"Leukaemia Markers. Proceedings of the Leukaemia Marker Conference, Vienna","year":"1981","author":"Zeigler A.","key":"e_1_2_1_38_1"},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313028009086807"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900040306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900040306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T21:46:26Z","timestamp":1736804786000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900040306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1002\/hon.2900040306"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900040306","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"type":"print","value":"0278-0232"},{"type":"electronic","value":"1099-1069"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}