{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T09:30:41Z","timestamp":1780392641396,"version":"3.54.1"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"vor","delay-in-days":7553,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The T1 surface antigen (CD5,p67) expression on blood lymphocytes (PBL) and lymphoid cells from lymph node biopsies (LN) from 31 patients with B\u2010cell chronic lymphocytic leukemia (B\u2010CLL) and 79 with B non\u2010Hodgkin lymphoma (B\u2010NHL), was detected in 25 B\u2010CLL (80 per cent) and in 11 B\u2010NHL (13 per cent) belonging to the following histologic subtypes: lymphocytic of CLL type (DLWD) one case, lymphoplasmacytoid (DLWD) four cases, centrocytic (DLPD) five cases, immunoblastic (DH) one case<\/jats:p><jats:p>All B\u2010CLL and the T1 + B\u2010NHL were also tested with monoclonal antibodies against the Common Acute Lymphoblastic Leukemia Antigen, B cells (FMC7, FMC8, BA1, Y29\u201355), T cells (OKT11a), HLA\u2010DR and HLA\u2010DQ monomorphic determinants<\/jats:p><jats:p>All the B\u2010CLL and the T1 + B\u2010NHL were CALLA<jats:sup>\u2010<\/jats:sup>, BA1<jats:sup>+<\/jats:sup>, Y29.55<jats:sup>+<\/jats:sup> . FMC7<jats:sup>+<\/jats:sup> cells were detected in large numbers six B\u2010CLL(three T1<jats:sup>+<\/jats:sup> and three T1<jats:sup>\u2010<\/jats:sup>) and in four centrocytic lymphomas. FMC8 reacted with 70 per cent of leukemias (where it stained 30 per cent of neoplastic cells) and with 8\/9 T1<jats:sup>+<\/jats:sup> B\u2010NHL. HLA\u2010DR and HLA\u2010DQ molecules were detected in 100 per cent and 90 per cent of cases respectively. <jats:italic>In vitro<\/jats:italic> treatment of HLA\u2010DQ<jats:sup>\u2010<\/jats:sup> or T1<jats:sup>\u2010<\/jats:sup> B\u2010CLL with phorbol ester TPA led to the expression of these antigens as well as of the receptors for Interleukin 2 and MLR3 activation antigen. Surface membrane Ig (SIg) was detected in 79 per cent of cases, its density measured by FACS analysis varied, even markedly, from case to case. Among the B\u2010CLL, cells with high SIg content were either T1<jats:sup>+<\/jats:sup> or T1<jats:sup>\u2010<\/jats:sup> and more likely FMC<jats:sup>+<\/jats:sup>. The SIg<jats:sup>\u2010<\/jats:sup> cases were seven B\u2010CLL (five T1<jats:sup>+<\/jats:sup> and two T1<jats:sup>\u2010<\/jats:sup>) and two B\u2010NHL, in which, however, cytoplasmic IgM was detected<\/jats:p><jats:p>This study reveals the existence of four major B\u2010CLL subgroups: T1<jats:sup>\u2010<\/jats:sup> SIg<jats:sup>\u2010<\/jats:sup>, T1<jats:sup>+<\/jats:sup> SIg<jats:sup>\u2010<\/jats:sup>, T1<jats:sup>+<\/jats:sup> SIg<jats:sup>+<\/jats:sup>, T1<jats:sup>\u2010<\/jats:sup> SIg<jats:sup>+<\/jats:sup>. It also indicates that the T1 antigen may be transitionally present during B\u2010cell differentiation and that its expression may precede that of SIg as supported by the <jats:italic>in vitro<\/jats:italic> studies. In addition, the finding that some B\u2010NHL are T1<jats:sup>+<\/jats:sup> suggests that they derive similarly to the B\u2010CLL from a common progenitor.<\/jats:p>","DOI":"10.1002\/hon.2900040308","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:13:53Z","timestamp":1171887233000},"page":"237-248","source":"Crossref","is-referenced-by-count":18,"title":["Expression of the T1 (CD5, p67) surface antigen in B\u2010CLL and B\u2010NHL and its correlation with other B\u2010cell differentiation markers"],"prefix":"10.1002","volume":"4","author":[{"given":"Domenico","family":"Delia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Bonati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Giardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo De","family":"Braud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Cattoretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Rilke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"83","DOI":"10.4049\/jimmunol.126.1.83","article-title":"Monoclonal antibody (BA1) reactive with cells of human B lymphocytes lineage","volume":"126","author":"Abramson C. 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