{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:11:39Z","timestamp":1697976699327},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T00:00:00Z","timestamp":1173139200000},"content-version":"vor","delay-in-days":7461,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1986,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A monoclonal antibody, SN3, has been prepared against a cell membrane fraction of the pre\u2010B leukemic cell line NALM\u20101. By radioimmunoassay, SN3 reacted with four of four non\u2010T\/non\u2010B, two of two pre\u2010B and one of three leukemic B cell lines. The reagent was unreactive, however, with established leukemic T and myelomonocytic cell lines or normal B cell lines. On immunohistochemical assays on frozen sections of nine reactive lymph nodes and three spleens, SN3 showed a preferential binding to 50\u201395 per cent mantle zone (MZ) cells and 5\u201320 per cent interfollicular or red pulp B\u2010lymphocytes. This was uninhibited by pre\u2010incubation with heterologous anti\u2010HLA\u2010DR or anti\u2010\u03b4 reagents. SN3 was unreactive with normal germinal centre (GC), epidermal or Langherhans cells but did react with less than 1 per cent thymic B\u2010lymphocytes. In eight follicular small cleaved cell lymphomas tested SN3 exhibited three patterns of reactivity: (1) peripheral follicular, (2) combined peripheral and central follicular, and (3) combined follicular and interfollicular. Three follicular lymphomas were essentially SN3<jats:sup>\u2010<\/jats:sup>. In three diffuse small lymphocytic lymphomas, SN3 showed patchy areas of reactivity unassociated with proliferation centres. In four diffuse B\u2010cell lymphomas (one mixed small and large cell, two large non\u2010cleaved cell, and one small non\u2010cleaved (Burkitt) cell), SN3 reactivity was uniformly distributed in the majority (60\u201390 per cent) of the cells. SN3 was unreactive with one diffuse B\u2010large cell lymphoma, three nodal T\u2010cell lymphomas and three cases of mycosis fungoides. The findings indicate that (1) SN3 detects an antigen that is present in subpopulations of normal MZ cells, (2) the antigen is also detected in GC cells undergoing lymphomatous transformation but is not readily detected in normal GC cells, and (3) the antigen is also expressed in subpopulations of diffuse B\u2010 but not T\u2010cell lymphomas.<\/jats:p>","DOI":"10.1002\/hon.2900040402","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:13:52Z","timestamp":1171887232000},"page":"251-259","source":"Crossref","is-referenced-by-count":4,"title":["Follicular mantle zone cell subpopulations detected by monoclonal antibody SN3"],"prefix":"10.1002","volume":"4","author":[{"given":"M.","family":"Barcos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Pollard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Fukukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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