{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T11:37:44Z","timestamp":1697974664529},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":7275,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1987,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Expression of the granulocyte antigen Leu M\u20101 is characteristic of Reed\u2013Sternberg cells and the related mononuclear cells of Hodgkin's Disease. Leu M\u20101 has been proposed as a specific immunological marker for Hodgkin's Disease which may be otherwise difficult to distinguish both morphologically and immunologically from non Hodgkin's lymphomas of peripheral T\u2010cell type. In the present study the comparative expression of Leu M\u20101 in Hodgkin's Disease and peripheral T cell lymphoma was studied in a series of 43 cases including 25 cases of Hodgkin's Disease and 18 cases of immunologically documented peripheral T cell lymphoma. Leu M\u20101 staining by avidin\u2010biotin\u2010peroxidase complex technique in acetone fixed frozen sections was observed in 22 of 25 cases of Hodgkin's Diseases, (2 of 3 cases of lymphocyte predominant Hodgkin's Disease and 1 case of mixed cellularity were negative) and in 4 of 18 cases of peripheral T cell lymphoma. The pattern of staining in the peripheral T cell lymphomas was indistinguishable from that observed in Hodgkin's Disease in 2 of the cases. Leu M\u20101 staining appears to be of limited diagnostic value in the differential diagnosis of Hodgkin's Disease and T cell lymphoma. Absence of Leu M\u20101 staining in frozen tissue however, makes a diagnosis of Hodgkin's Disease (with the exception of the lymphocyte predominant form) unlikely.<\/jats:p>","DOI":"10.1002\/hon.2900050205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:13:41Z","timestamp":1171887221000},"page":"107-114","source":"Crossref","is-referenced-by-count":6,"title":["Leu M\u20101 antigen: Comparative expression in hodgkin's disease and T cell lymphoma"],"prefix":"10.1002","volume":"5","author":[{"given":"J. A.","family":"Strauchen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Breakstone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850215)55:4<728::AID-CNCR2820550409>3.0.CO;2-S"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.1.29"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/29.4.6166661","article-title":"Use of avidin biotin peroxidase complex (ABC) in immunoperoxidase techniques: A comparison between ABC and unlabelled antibody (PAP) procedures","volume":"29","author":"Hsu S. M.","year":"1981","journal-title":"J. Histochem. Cytochem."},{"key":"e_1_2_1_5_1","first-page":"209","article-title":"Phenotype expression of Hodgkin's and Reed\u2010Sternberg cells in Hodgkin's Disease","volume":"118","author":"Hsu S. M.","year":"1985","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_6_1","first-page":"416","article-title":"Utility of Leu M\u20101 monoclonal antibody in the differential diagnosis of Hodgkin's Disease","volume":"110","author":"Hyder D. M.","year":"1986","journal-title":"Arch. Pathol. Lab. Med."},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(1984)54:4<644::AID-CNCR2820540410>3.0.CO;2-A"},{"key":"e_1_2_1_8_1","first-page":"244","article-title":"Leu M\u20101\u2014A marker for Reed\u2010Sternberg cells in Hodgkin's Disease. An immunoperoxidase study of paraffin embedded tissues","volume":"19","author":"Pinkus G. S.","year":"1985","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198604000-00001"},{"key":"e_1_2_1_10_1","first-page":"293","article-title":"Immunopathology of Hodgkin's Disease: Characterisation of Reed\u2010Sternberg cells with monoclonal antibodies","volume":"123","author":"Strauchen J. A.","year":"1986","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80226-4"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900050205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900050205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T19:30:32Z","timestamp":1697830232000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900050205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,4]]}},"alternative-id":["10.1002\/hon.2900050205"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900050205","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4]]}}}