{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:35:43Z","timestamp":1760297743324},"reference-count":11,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":7184,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirty\u2010three patients with multiple myeloma (11 untreated, 15 refractory and seven relapsed patients) have received vincristine and adriamycin infusion therapy with oral dexamethasone (VAD). The median number of courses received was five. In addition 16 patients with lymphoid malignancy have received a median of four courses of VAD.<\/jats:p><jats:p>Three patients who relapsed after VAD have received further VAD therapy making 52 patient treatments assessable for toxicity. Ten per cent had nausea, 4 per cent vomiting, 4 per cent total alopecia, 25 per cent constipation, 33 per cent paraesthesiae, 8 per cent proximal myopathy, 33 per cent dyspepsia, 23 per cent proven bacteraemia, and 19 per cent chest infections. Infections were <jats:italic>not<\/jats:italic> usually associated with neutropenia. Shingles was seen in four patients with myeloma, but none of the patients with lymphoid malignancy.<\/jats:p><jats:p>The response rate in myeloma was 9\/11, for previously untreated patients, 3\/7 for relapsed, and 8\/15 for refractory patients. Responses have been seen in other lymphoid malignancies\u20141\/2 patients with relapsed acute lymphoblastic leukaemia had a complete remission. Two out of seven patients with chronic lymphocytic leukaemia achieved a partial remission, and a further three had a clinical improvement. Three out of six patients with non\u2010Hodgkin lymphoma and one patient with macroglobulinaemia achieved a partial remission.<\/jats:p>","DOI":"10.1002\/hon.2900050308","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:53:29Z","timestamp":1171918409000},"page":"213-222","source":"Crossref","is-referenced-by-count":19,"title":["VAD chemotherapy\u2014toxicity and efficacy\u2014in patients with multiple myeloma and other lymphoid malignancies"],"prefix":"10.1002","volume":"5","author":[{"given":"H.","family":"Anderson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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P.","year":"1971","journal-title":"Cancer Res."},{"key":"e_1_2_1_5_1","first-page":"145","article-title":"Proposed guidelines for protocol studies II. Plasma cell myeloma","volume":"4","author":"Chronic Leukaemia\u2010Myeloma Task Force","year":"1973","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840615)53:12<2601::AID-CNCR2820531205>3.0.CO;2-D"},{"key":"e_1_2_1_8_1","first-page":"17","volume-title":"Manual of Cancer Chemotherapy","author":"Monfardini S.","year":"1981"},{"key":"e_1_2_1_9_1","first-page":"105","volume-title":"Neoplastic Diseases of the Blood","author":"Rai K. 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