{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T03:17:00Z","timestamp":1789096620483,"version":"build-2803163510"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":7000,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between presenting skeletal X\u2010ray findings and survival in multiple myeloma was assessed in 172 consecutive patients treated at this institute. All patients were investigated, treated and followed up according to one protocol. The shortest survival was seen in those with normal X\u2010rays (3\u2010year actuarial 11 per cent) and the longest in those with minimal lytic changes (3\u2010year actuarial 44 per cent). Patients with osteoporosis alone and those with extensive lytic lesions had intermediate survivals of 32 per cent and 33 per cent respectively. Of the other major prognostic features only anaemia demonstrated a significant correlation with X\u2010ray findings in terms of survival (<jats:italic>p<\/jats:italic> &lt; 0.001) suggesting that those with normal X\u2010rays may have a more diffuse marrow involvement accounting for their poor prognosis.<\/jats:p><jats:p>The response on bone X\u2010rays in 102 patients who completed nine cycles of chemotherapy was also analysed. Patients with evidence of healing had a 3\u2010year actuarial survival of 37 per cent, those with progression 36 per cent and those with stable X\u2010rays 65 per cent (<jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p>Normal bone X\u2010rays at presentation and radiological evidence of healing following therapy appear to be bad prognostic signs in multiple myeloma.<\/jats:p>","DOI":"10.1002\/hon.2900060102","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:52:15Z","timestamp":1171918335000},"page":"1-6","source":"Crossref","is-referenced-by-count":23,"title":["The prognostic significance of X\u2010ray changes at presentation and reassessment in patients with multiple myeloma"],"prefix":"10.1002","volume":"6","author":[{"given":"David B.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Howard","family":"Scarffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Eddleston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"145","article-title":"National Cancer Institute: Proposed guidelines for protocol studies II. Plasma cell myeloma","volume":"4","author":"Chronic Leukemia\u2010Myeloma Task Force","year":"1973","journal-title":"Cancer Chemother. Rep."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<842::AID-CNCR2820360303>3.0.CO;2-U"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02758.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/58.2.178"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1969.tb00441.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/104.3.509"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb00747.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1182\/blood.V55.6.1011.1011","article-title":"A new improved clinical staging system for multiple myeloma based on analysis of 123 treated patients","volume":"55","author":"Merlini G.","year":"1968","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/clinchem\/28.11.2254","article-title":"Radioimmunoassay of free light chains of immunoglobulins in urine","volume":"28","author":"Robinson E. L.","year":"1982","journal-title":"Clin. Chem."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(93)90004-O"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb05733.x"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900060102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900060102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T14:23:13Z","timestamp":1697984593000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900060102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/hon.2900060102"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900060102","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}