{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T12:11:34Z","timestamp":1697976694094},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":6514,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new monoclonal antibody (MAB), IA61gG2a, has been derived from Balb\/c mice after immunization with T\u2010cell chronic lymphocytic leukemia (T\u2010CLL). This monoclonal antibody, 1A6 was tested on normal human peripheral blood cells, leukemia patient's cells and leukemia\u2010lymphoma cell lines. The results demonstrated that this antibody reacts with normal human T and B cells, but not with erythrocytes, granulocytes or platelets. Further examinations showed 10\/11 leukemic patient cell types were positive with 1A6. In contrast, many leukemia\u2010lymphoma cell lines were negative (14\/17), i.e. T and B leukemia lymphoma cell lines, non\u2010T and non\u2010B leukemia cell lines as examined by complement mediated cytotoxicity test and immunofluorescence test. Other prominent characteristics of 1A6 MAB have been demonstrated, which include inhibition of myeloid colony formation (CFU\u2010C) and suppression of human natural killer cell cytotoxicity (NKCC). These results suggest that 1A6 is a common marker for normal T, B, NK cells and leukemic patients cells having T and B cell origin, but 1A6 antigen is not expressed on many leukemia lymphoma cell lines. Therefore, it could be useful for studying malignant transformation of lymphoid cells.<\/jats:p>","DOI":"10.1002\/hon.2900070306","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:06:48Z","timestamp":1171915608000},"page":"233-242","source":"Crossref","is-referenced-by-count":0,"title":["A monoclonal antibody 1A6 to T\u2010cell recognizes a common antigen expressed on lymphocytes from normal and leukemic patients, and inhibits nk cell activity"],"prefix":"10.1002","volume":"7","author":[{"given":"Hiroyuki","family":"Togashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamdooh","family":"Ghoneum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuo","family":"Takasugi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshi","family":"Kasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Mugishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Billing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul. 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