{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:15:03Z","timestamp":1760044503472},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,7]],"date-time":"2007-03-07T00:00:00Z","timestamp":1173225600000},"content-version":"vor","delay-in-days":6215,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1990,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We studied rearrangement of human T cell receptor genes (TCR) of C\u03b2, C\u03b3, V\u03b3 and J\u03b3 in 34 cases of adult T cell leukemia\/lymphoma (ATLL), consisting of 29 cases with monoclonally integrated HTLV\u2010I proviral DNA (ATLL\u2010W) and five without monoclonal integration (ATLL\u2010O), in comparison with 12 cases of other peripheral T cell lymphomas (non\u2010ATLL).<\/jats:p><jats:p>All cases of both ATLL and non\u2010ATLL showed some rearrangement of T cell receptor genes (TCRs) of C\u03b2. C\u03b3, V\u03b3, or J\u03b3. Rearrangement of TCR\u03b2 was found in 28 of 29 cases of ATLL\u2010W, all cases of ATLL\u2010O. and eight of 12 cases of non\u2010ATLL. Rearrangement of TCR\u03b3 was observed in 21 of 22 cases of ATLL\u2010W. and in all cases of ATLL\u2010O and non\u2010ATLL. In TCR\u03b3, rearrangement of C\u03b3 was seen in six of 20 cases of ATLL\u2010W. none of three ATLL\u2010O cases and three of six cases of non\u2010ATLL. V\u03b3 rearrangement occurred in 14 of 18 cases of ATLL\u2010W, one of two cases of ATLL\u2010O, and three of six cases of non\u2010ATLL. Rearrangement of J\u03b3, was found in 16 of 22 cases of ATLL\u2010W, two of five ATLL\u2010O cases, and six of seven non\u2010ATLL cases. Rearrangement was more frequent in ATLL\u2010W than in ATLL\u2010O and non\u2010ATLL. The incidence rate of rearrangement of V\u03b3 families of V\u03b31, V\u03b32, and V\u03b33 was nearly the same in each group, except for deletion of V\u03b33, which was often observed in ATLL but was absent in non\u2010ATLL. These results indicate the usefulness of detection of TCR and HTLV\u2010I proviral DNA to differentiate ATLL from other T cell malignancies.<\/jats:p>","DOI":"10.1002\/hon.2900080207","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:03:19Z","timestamp":1171915399000},"page":"111-118","source":"Crossref","is-referenced-by-count":9,"title":["Rearrangement of human T cell receptor \u03b2 and \u03b3 chain genes in adult t cell leukemia\/lymphoma"],"prefix":"10.1002","volume":"8","author":[{"given":"K.","family":"Ohshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Satoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,7]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1182\/blood.V69.3.968.968","article-title":"T cell \u03b3 gene rearrangements in hematologic neoplasms","volume":"69","author":"Asou N.","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1182\/blood.V58.3.645.645","article-title":"Surface phenotype of Japanese adult T cell leukemia cells characterized by monoclonal antibodies","volume":"58","author":"Hattori T.","year":"1981","journal-title":"Blood"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/316828a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90140-0"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/322836a0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830171121"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/316464a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.4.1224"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.12.7415"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3079918"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1002\/j.1460-2075.1985.tb03917.x","article-title":"Heterogeneity of T cell \u03b2 chain gene rearrangements in human leukemias and lymphomas","volume":"4","author":"Rabbits T. 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RNA. and cell membrane level","volume":"138","author":"Van Dongen J. J. M.","year":"1987","journal-title":"J. Immunol."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/308145a0"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.8.2534"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900080207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900080207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T18:39:03Z","timestamp":1697999943000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900080207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,3]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,3]]}},"alternative-id":["10.1002\/hon.2900080207"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900080207","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,3]]}}}