{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T10:46:35Z","timestamp":1698144395609},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5631,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>One hundred and seventy\u2010one consecutive febrile episodes occurring in 130 neutropenic adult patients with hematological malignancies (mainly acute leukemia) were empirically treated with a combination antibiotic therapy consisting of ceftazidime (100 mg\/kg\/day) + amikacin (15 mg\/kg\/day). Of these, 161 were evaluable.<\/jats:p><jats:p>In the majority of episodes (75 per cent) documented infections were identified as a cause of fever. There were 73 bacteremias (34 Gram\u2010negative, 29 Gram\u2010positive, 10 polymicrobial). One third of patients had pneumonia. Cure without change of the initial regimen was achieved in 45\/73 (62 per cent) bacteremic episodes and in 12\/13 episodes of microbiologically documented infections without bacteremia. There were 35 clinically documented infections and 26 (74 per cent) of these were cured. Of the 40 patients presenting with possible infections 26 (65 per cent) were cured.<\/jats:p><jats:p>Overall, cure without modification of the initial antibiotic combination was achieved in 109\/161 episodes (68 per cent). In spite of the frequent occurrence of persistent neutropenia (82 per cent), the infectious mortality was low (8\u20136 per cent), and often due to superinfection. The deaths due to primary infections were 6\/161 (3\u20137 per cent). Side effects were mild and rare.<\/jats:p><jats:p>In our experience ceftazidime+amikacin was an effective and safe empirical regimen for this population of hematologic patients with persistent neutropenia and severe documented infections.<\/jats:p>","DOI":"10.1002\/hon.2900090304","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:02:30Z","timestamp":1171911750000},"page":"137-146","source":"Crossref","is-referenced-by-count":1,"title":["Ceftazidime and amikacin as empiric antibiotic therapy of febrile granulocytopenic patients with hematological malignancies. Report of 171 consecutive episodes"],"prefix":"10.1002","volume":"9","author":[{"given":"G.","family":"Todeschini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Veneri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Carlini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pizzolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ambrosetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bonesi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Cassibba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Vinante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Meneghini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Perona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90140-4"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90242-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197605000-00005"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_A.93"},{"issue":"4","key":"e_1_2_1_7_1","first-page":"169","article-title":"Ergebnisse aus mehreren verschiedenen kontrollierten studien mit ceftazidim in der behandlung von infektionene bei immunosupprimierten patienten","volume":"15","author":"De Pauw B. E.","year":"1987","journal-title":"Infection"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702123160713"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712313172703"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/12.suppl_A.101"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/17.suppl_A.41"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197402)33:2<568::AID-CNCR2820330236>3.0.CO;2-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198702123160713"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90243-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01642871"},{"key":"e_1_2_1_16_1","unstructured":"Perona G. Cetto G. L. Todeschini G. Vinante F. Benini F.(11\u201312 November1983).Ceftazidime in treatment of infection in granulocytopenic patients with cancer. 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