{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:40:25Z","timestamp":1698126025010},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5539,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the incidence of carcinoma of the stomach has steadily declined over the last 50 years. approximately 23 200 new cases will be diagnosed in the United States this year and 13 700 patients will die. Despite marked improvement in operative techniques, fewer than 20 per cent of those diagnosed with gastric cancer beyond the most superficial levels of invasion will survive for over five years. Gastric tumours spread by local, lymphatic, and aggressive intra\u2010peritoneal routes as well as hematogenous dissemination. Over 87 per cent of recurrences have local or regional components.<\/jats:p><jats:p>Radiation therapy may decrease local and regional recurrences in those patients with transmural tumours. The neoadjuvant use of etoposide, adriamycin, and platinum may yield complete clinical and pathologic responses in patients found to have \u2018unresectable\u2019 tumours. Other chemotherapy regimens have been shown to have some effect on advanced disease and may have a role in the neoadjuvant setting.<\/jats:p><jats:p>Our current recommendations for the treatment of gastric cancer in a controlled trial setting would be neoadjuvant chemotherapy followed by R<jats:sub>2<\/jats:sub> resection, postoperative intraoperative radiation therapy with the possibility of postoperative \u00b1 chemotherapy. Hopefully, this aggressive multimodality approach will significantly improve the five year survival for this disease.<\/jats:p>","DOI":"10.1002\/hon.2900100107","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:57:31Z","timestamp":1171911451000},"page":"31-35","source":"Crossref","is-referenced-by-count":3,"title":["Gastric cancer\u2014surgical approach"],"prefix":"10.1002","volume":"10","author":[{"given":"James L.","family":"Weese","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Nussbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90239-8"},{"key":"e_1_2_1_3_1","unstructured":"American Cancer Society(1990).Cancer Facts and Figures8."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(89)90710-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198212001-00012"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01658794"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)44079-X"},{"key":"e_1_2_1_8_1","unstructured":"Coit D. G. Brennan M. F. et al. (1986).Gastric cancer. In: Moody F. G. et al. eds.Surgical Treatment of Digestive Disease Chicago239\u2013256."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830915)52:6<1113::AID-CNCR2820520630>3.0.CO;2-T"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(82)90377-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02468883"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00402474"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800750106"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.11.1249"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19891115)64:10<2053::AID-CNCR2820641014>3.0.CO;2-J"},{"key":"e_1_2_1_16_1","first-page":"683","volume-title":"Maingot's Abdominal Operations","author":"Rosin R. D.","year":"1989"},{"issue":"9","key":"e_1_2_1_17_1","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1200\/JCO.1989.7.9.1318","article-title":"Preoperative chemotherapy in locally advanced and non\u2010resectable gastric cancer: A phase II study with etoposide, doxorubicin, and cisplatin","volume":"7","author":"Wilke H.","year":"1989","journal-title":"J. Clin. Oncol."}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900100107","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900100107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:12:18Z","timestamp":1698077538000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900100107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/hon.2900100107"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900100107","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}