{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:40:29Z","timestamp":1698126029249},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5479,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We reported a new monoclonal antibody, designated FUB\u20101, reacting with normal and neoplastic large lymphoid cells. FUB\u20101 was produced using a Burkitt's lymphoma cell line (HBL\u20105) as an immunogen. Its immunoglobulin subtype was IgM. The determinant was not on the surface but in the cytoplasm. Western blotting analysis revealed that the molecular weight of the antigen was 52000 dalton. In the normal lymphoid tissue, FUB\u20101 reacted with large lymphoid cells, but not with small or medium\u2010sized lymphoid cells or plasma cells. In addition, the FUB\u20101 antigen was not found in resting cells in the peripheral blood (PB), but it was induced on mononuclear cells of PB by addition of PWM or PMA. In the B\u2010cell lymphomas tested, FUB\u20101 reacted with small cleaved cell lymphomas (3\/12), large cell lymphomas (7\/10), Burkitt's lymphomas (4\/4) and immunoblastic lymphomas (2\/2), but not with small cell lymphomas (0\/3) or intermediate lymphocytic lymphomas (0\/8). These findings indicate that the FUB\u20101 antigen appears to be expressed on normal lymphoid cells during blastoid transformation and on neoplastic large lymphoid cells. FUB\u20101 also reacted with normal glandular epithelium and various adenocarcinomas.<\/jats:p><jats:p>FUB\u20101 may be useful to investigate the mechanism of <jats:italic>in vitro<\/jats:italic> blastoid transformation or activation of lymphoid cells.<\/jats:p>","DOI":"10.1002\/hon.2900100205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:53:44Z","timestamp":1171911224000},"page":"95-104","source":"Crossref","is-referenced-by-count":0,"title":["A new monoclonal antibody which binds to the cytoplasm of large cell lymphomas"],"prefix":"10.1002","volume":"10","author":[{"given":"Naoya","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayuri","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiko","family":"Tominaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V60.1.1.1","article-title":"Surface marker on leukemia and lymphoma cells: Recent advances","volume":"60","author":"Foon K. 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