{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:47:56Z","timestamp":1793468876823,"version":"4.5.0"},"reference-count":15,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1992,5]]},"abstract":"Abstract<\/jats:title>\n \n The authors have studied proliferation (growth fractions) in non\u2010Hodgkin's lymphomas (NHL) using an immunohistochemical double staining technique with the monoclonal antibody (MoAb), Ki\u201067, in order to clarify the relationships between histologic type, proliferation and prognosis. The percentages of Ki\u201067 positive (Ki\u201067\n +<\/jats:sup>\n ) cells in B cell lymphomas were higher for diffuse lymphomas than for follicular lymphomas and increased in order from small to large cell types. In addition, the percentage of Ki\u201067\n +<\/jats:sup>\n cells in B cell lymphomas inversely correlated with survival in months (\n n<\/jats:italic>\n = 33\n r<\/jats:italic>\n = \u20100\u00b754\n p<\/jats:italic>\n < 0\u00b701). These results indicate that the percentage of Ki\u201067\n +<\/jats:sup>\n cells in B cell lymphomas correlates with histologic type and prognosis. Although the prognosis of T cell lymphomas is considered worse than that of B cell lymphomas, the percentage of Ki\u201067\n +<\/jats:sup>\n cells was lower, in general, in T cell lymphomas than in B cell lymphomas. These data indicate that proliferation in T cell lymphomas does not correlate with survival.\n <\/jats:p>","DOI":"10.1002\/hon.2900100306","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T12:58:38Z","timestamp":1171889918000},"page":"163-169","source":"Crossref","is-referenced-by-count":15,"title":["Proliferation in non\u2010hodgkin's lymphomas as determined by immunohistochemical double staining for Ki\u201067"],"prefix":"10.1002","volume":"10","author":[{"given":"Kunihiko","family":"Tominaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nozawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310104"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80181-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198609000-00003"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890415)63:8<1607::AID-CNCR2820630827>3.0.CO;2-1"},{"key":"e_1_2_1_6_2","first-page":"327","article-title":"Cell proliferation in non\u2010Hodgkin's lymphomas. Digital image analysis of Ki\u201067 antibody staining","volume":"134","author":"Schwartz B. R.","year":"1989","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_7_2","first-page":"755","article-title":"Some problems on the histopathological diagnosis of non Hodgkin's malignant lymphoma\u2014a proposal for a new type","volume":"29","author":"Suchi T.","year":"1979","journal-title":"Acta Pathol. Jpn."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_9_2","first-page":"291","article-title":"Periodate\u2010lysine\u2010paraformaldehyde fixative a new fixative of immuno\u2010electron microscopy","volume":"14","author":"McIean I. W.","year":"1966","journal-title":"J. Histochem. Cytochem."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.4.1710"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020406"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt1961.27.363"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1159\/000205957"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(87)80384-2"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(90)90148-X"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhon.2900100306","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2900100306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T17:35:11Z","timestamp":1693589711000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2900100306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":15,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1002\/hon.2900100306"],"URL":"https:\/\/doi.org\/10.1002\/hon.2900100306","archive":["Portico"],"relation":{},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}