{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T20:47:29Z","timestamp":1698353249273},"reference-count":20,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5418,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010five patients with low grade non\u2010Hodgkin's lymphomas were studied with respect to the fraction of S\u2010phase cells in fresh tumour material by flow cytometric analysis. Patients with stage I lymphomas were treated with radiotherapy, patients with stage II\u2010IV lymphomas with Prednimustine (Sterecyt<jats:sup>R<\/jats:sup>). Patients with lymphocytic lymphomas of CLL type were only treated if they had symptoms. Median S\u2010phase fraction in the samples was 2\u20100 per cent. A significantly shorter survival was found for patients with lymphocytic lymphomas with S\u2010phase fractions &gt;2\u00b70 per cent compared with cases showing lower S\u2010phase fractions. No significant difference in survival was found in the subgroups of immunocytic or follicular and follicular diffuse centroblastic\/centrocytic lymphomas. In a Cox multivariate analysis, in which also age, constitutional symptoms, stage and morphology were included, the fraction of S\u2010phase cells was found to be a statistically significant, prognostic parameter for low grade lymphomas, mainly due to the result in the subgroup of lymphocytic lymphomas.<\/jats:p>","DOI":"10.1002\/hon.2900100307","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:58:38Z","timestamp":1171907918000},"page":"171-179","source":"Crossref","is-referenced-by-count":5,"title":["\u2018Aggressive\u2019 low grade lymphocytic lymphomas can be identified by flow cytometric s\u2010phase determinations"],"prefix":"10.1002","volume":"10","author":[{"given":"J.","family":"Lindh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Jonsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Lenner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-1-10"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1182\/blood.V58.3.592.592","article-title":"The treatment of advanced stage favourable histology non\u2010Hodgkin's lymphoma: A preliminary report of a randomized trial comparing single agent chemotherapy, combination chemotherapy and whole body irradiation","volume":"58","author":"Hoppe R. 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