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Reactive hemophagocytic syndrome was a common finding, causing significant morbidity and mortality. Peripheral lymphadenopathy was absent (by case selection), but involvement of the liver, spleen and paraaortic lymph nodes could be demonstrated in some cases. However, in some patients, the involvement was apparently restricted to the bone marrow. Involvement of the bone marrow was often subtle, and could be missed on casual examination. Immunohistochemical studies on eight cases showed that four exhibited a B\u2010cell phenotype. three a T\u2010cell phenotype and one a non\u2010T non\u2010B phenotype. The prognosis was poor, with survival being measured in days to weeks in most patients.<\/jats:p>","DOI":"10.1002\/hon.2900100504","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:57:43Z","timestamp":1171907863000},"page":"261-271","source":"Crossref","is-referenced-by-count":18,"title":["Large cell lymphoma with initial presentation in the bone marrow"],"prefix":"10.1002","volume":"10","author":[{"given":"K. F.","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. K. C.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. C.","family":"Chu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. P. 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