{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:19:01Z","timestamp":1758709141459},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":5173,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult T cell leukemia\/lymphoma (ATLL) is a mature T cell malignancy, especially derived from the CD4 positive T cell. To characterize the T cell, we examined the representation of T cell antigen receptor variable region, using the monoclonal antibodies [\u03b2 V 5 (a), \u03b2 V 5 (b), \u03b2 V 6 (a), \u03b2 V 8 (a), \u03b2 V 12 (a), \u03b1 V 2 (a), \u03b1\u2010\u03b2 V (a)]. Clinicopathologically we classified the lymph nodes of patients with ATLL into three states (1) human T cell leukemia virus type I (HTLV\u2010I) associated lymphadenitis, reactive state; (2) incipient ATLL, early or pre\u2010neoplastic state; and (3) ATLL, neoplastic state. The lymph nodes of all three states were composed of unvarying CD4 positive T cells. Most of the lymph nodes with ATLL consistently presented \u03b1 V 2 antigen, but no others. In HTLV\u2010I associated lymphadenitis, only a few cells reacted for \u03b1 V 2, as in non\u2010specific lymphadenitis without ATLL features. One of three cases with incipient ATLL presented \u03b1 V 2. The selective expression of T cell antigen receptor V region might be associated with the presence of HTLV\u2010I encoded superantigen, similar to human immunodeficiency virus (HIV).<\/jats:p>","DOI":"10.1002\/hon.2900110305","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:55:57Z","timestamp":1171907757000},"page":"147-154","source":"Crossref","is-referenced-by-count":2,"title":["Restriction of T cell receptor variable region in lymph nodes of adult T cell leukemia\/lymphoma"],"prefix":"10.1002","volume":"11","author":[{"given":"Koichi","family":"Ohshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Kobari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Sumiyosi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.10.6476"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-8-1641"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T cell leukemia: clinical hematolaogic features of 16 cases","volume":"50","author":"Uchiyama T.","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_5_2","first-page":"357","article-title":"Comparison of clinical, morphologic and immunologic characteristics of adult T\u2010cell leukemia\u2010lymphoma and cutaneous T\u2010cell lymphoma","volume":"9","author":"Shimoyama M.","year":"1979","journal-title":"J. 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Pathol."},{"key":"e_1_2_1_23_2","first-page":"17","article-title":"Cutaneous T\u2010cell lymphoma cells employ a restricted range of T\u2010cell antigen receptor variable region genes","volume":"136","author":"Jack A. S.","year":"1990","journal-title":"Am. J. Pathol."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02890410"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.12.3618"},{"key":"e_1_2_1_26_2","first-page":"755","article-title":"Some problems on the histopathological diagnosis of Non\u2010Hodgkin's malignant lymphoma\u2014A proposal of a new type","volume":"29","author":"Suchi T.","year":"1979","journal-title":"Acta. Pathol. 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