{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T02:41:51Z","timestamp":1761100911808,"version":"3.33.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":4808,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with non\u2010Hodgkin's lymphoma (NHL) who fail conventional chemotherapy have a dismal outcome. Reports from single institutions utilizing high\u2010dose chemoradiotherapy plus Autologous Bone Marrow Transplantation (ABMT) in this setting suggest three\u2010year disease\u2010free survival between 15\u201360 per cent. From 1985 to 1989 the Southwest Oncology Group performed a prospective multi\u2010institutional study involving ABMT in relapsed\/refractory NHL.<\/jats:p><jats:p>Forty\u2010five patients, ages 6\u201360 (median 38), with relapsed NHL were treated with high\u2010dose cyclophosphamide (60 mg\/kg\/d \u00d7 2), total body irradiation (200 cGy\/d \u00d7 6), and autologous unpurged bone marrow. Histologic subtypes included high grade lymphoma (10), intermediate grade lymphoma (33), and low grade lymphoma (2). Disease status pre\u2010ABMT was sensitive relapse (16), resistant relapse (13), and untreated relapse (16).<\/jats:p><jats:p>The actuarial three\u2010year event\u2010free survival and overall survival for all patients were 27 per cent and 38 per cent respectively. Causes of failure included regimen\u2010related deaths (4), lack of response (10), or tumour progression (20) which occurred at a median of 5 months (1\u201322) post\u2010ABMT and usually at previous sites of involvement. Response to salvage therapy pre\u2010ABMT, a reflection of a tumour's biological behaviour, was the most important predictor of good outcome post\u2010ABMT.<\/jats:p><jats:p>This study confirms that a significant number of patients with recurrent NHL can achieve prolonged disease\u2010free survival after ABMT.<\/jats:p>","DOI":"10.1002\/hon.2900120205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:53:24Z","timestamp":1171907604000},"page":"75-85","source":"Crossref","is-referenced-by-count":8,"title":["Autologous bone marrow transplantation in adults with non\u2010Hodgkin's lymphoma: A southwest oncology group study"],"prefix":"10.1002","volume":"12","author":[{"given":"Ruben","family":"Saez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Dahlberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick R.","family":"Appelbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Hartsock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Lemaistre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR","given":"Charles A.","family":"Coltman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard I.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"issue":"2","key":"e_1_2_1_2_2","first-page":"2","article-title":"The role of chemotherapy in diffuse aggressive lymphoma","volume":"25","author":"Devita V. 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