{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T16:21:30Z","timestamp":1698510090662},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":4443,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cytokines and immune markers were assessed during the clinical management of 42 patients with multiple myeloma, MM. Of the patients 22\/42 (all with progressive disease) were studied from the time of diagnosis, through various treatment regimes, to remission, progression or death. 5\/42 patients had monoclonal gammopathy of undertermined significance (MGUS), 8\/42 others had either indolent MM or stable MM, and a further 7\/42 with progressive disease were also studied. IL\u20106, TNF\u2010\u03b1, IL\u20101\u03b1, IL\u20101\u03b2, \u03b22 microglobulin (\u03b22M), and neopterin were estimated in bloods taken under optimal conditions for cytokine detection. The levels were compared with a panel of samples from healthy volunteers. Both immunoreactive and bilogically active plasma IL\u20106 levels were measured. Pretreatment IL\u20106 levels (both immunoreactive and biologically active) were found to correlate with severity of disease. In 13\/22 patients with progressive disease who had been followed from the time of diagnosis over a 12\u2010month period or until death, pretreatment IL\u20106 levels were predictive of response to therapy. Elevated plasma levels of TNF\u2010\u03b1, \u03b22M and neopterin were found in patients with progressive multiple myeloma, and this correlated with renal impairment. The analytes measured during the course of chemotherapy did not show correlation with disease progression or response to therapy.<\/jats:p>","DOI":"10.1002\/hon.2900130204","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:52:53Z","timestamp":1171903973000},"page":"69-82","source":"Crossref","is-referenced-by-count":6,"title":["Multiple myeloma: An immunoclinical study of disease and response to treatment"],"prefix":"10.1002","volume":"13","author":[{"given":"P. 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