{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T05:10:19Z","timestamp":1698383419592},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T00:00:00Z","timestamp":1172793600000},"content-version":"vor","delay-in-days":4443,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previously diagnosed cases of hepatosinusoidal T\u2010cell lymphoma and malignant histiocytosis (MH) may include lymphoid neoplasms of natural killer (NK) cell lineage associated with Epstein\u2010Barr virus (EBV). Such hepatosinusoidal neoplasms were found to demonstrate hepatomegaly but not lymphadenopathy, and all were diagnosed by a liver biopsy. Sixteen adult patients diagnosed with hepatosinusoidal leukaemia\/lymphoma (six NK\u2010cell leukaemia\/lymphomas [NKLLs], five instances of MH, three T\u2010cell malignant lymphomas [T\u2010MLs], and two adult T\u2010cell leukaemia\/lymphomas [ATLLs] were examined for EBV by <jats:italic>in situ<\/jats:italic> hybridization, then were studied immunohistochemically and subjected to a DNA analysis. Among our five patients with MH, neoplastic cells showed T\u2010cells, but no histiocytic markers, and they were considered to have either a T\u2010cell or NK\u2010cell lineage. All NKLLs, MHs and T\u2010MLs, except for ATLLs accompanied by reactive hemophagocytic histiocytes, varied in number in each case. <jats:italic>In situ<\/jats:italic> hybridization revealed the presence of EBV in the nuclei of atypical cells in all of the six lymphoid neoplasms of NK\u2010cell lineage. Each case of MH and each T\u2010ML which represented EBV demonstrated no definite T\u2010cell or histiocytic markers. Patients with ATLL did not reveal EBV. In all patients with hemophagocytosis, EBV was present in the nuclei of the neoplastic lymphocytes, but not in the hemophagocytic cells. Finally, the 16 cases were reclassified into eight cases with EBV \u2010containing NKLLs, six T\u2010MLs, and two ATLLs. In addition, no true histiocytic neoplasms were observed. The mechanism of hemophagocytosis may be therefore the production of lymphokines (macrophage\u2010activating factors) by neoplastic lymphocytes. EBV\u2010associated hepatosinusoidal leukaemia\/lymphoma may thus contain a lymphoid neoplasm of NK\u2010cell lineage, which made it difficult to be distinguished from the previously designated malignant histiocytosis.<\/jats:p>","DOI":"10.1002\/hon.2900130205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:52:53Z","timestamp":1171903973000},"page":"83-97","source":"Crossref","is-referenced-by-count":7,"title":["Hepatosinusoidal leukaemia\/lymphoma consisting of epstein\u2010barr virus\u2010containing natural killer cell leukaemia\/lymphoma and T\u2010cell lymphoma; mimicking malignant histiocytosis"],"prefix":"10.1002","volume":"13","author":[{"given":"Kohichi","family":"Ohshima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Mizuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Akashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kousei","family":"Moriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yoneda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morishige","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,3,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.153.3.569"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2409597"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.1.209"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211","article-title":"Clonal disease of large granular lymphocytes","volume":"82","author":"Loughran T. 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