{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:44:02Z","timestamp":1786977842827,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81520108003"],"award-info":[{"award-number":["81520108003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670176"],"award-info":[{"award-number":["81670176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81830007"],"award-info":[{"award-number":["81830007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070204"],"award-info":[{"award-number":["82070204"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20180911"],"award-info":[{"award-number":["BK20180911"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001384","name":"Samuel Waxman Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008750","name":"Shanghai Hospital Development Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diffuse large B\u2010cell lymphoma (DLBCL) is a genetically heterogeneous disease with complex tumor microenvironment (TME) alterations. However, immune cell signatures of TME and their prognostic value remain unclear in DLBCL. We aimed to identify high\u2010risk DLBCL with specific immune cell signatures in TME. Clinical and gene expression data of DLBCL patients were obtained from previously reported retrospective datasets in Gene Expression Omnibus (GSE10846\n                    <jats:sup>6<\/jats:sup>\n                    and GSE53786\n                    <jats:sup>16<\/jats:sup>\n                    ) and a multi\u2010center prospective clinical trial NHL001 (NCT01852435). Patients treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0159) from GSE10846 were referred as training cohort for CHOP regimen, while patients treated with rituximab\u2010CHOP (R\u2010CHOP) regimen (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0192) from GSE10846 as training cohort for R\u2010CHOP regimen. Patients from NHL001 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a068) and GSE53786 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a057) were referred as validation cohorts for R\u2010CHOP regimen. CIBERSORT was applied to estimate the relative proportions of 22 subtype of immune cells. We established a prognostic model for model for R\u2010CHOP regimen included\u00a0Age, performance status, lactate dehydrogenase, T cells follicular helper and macrophages M0, defining a low\u2010risk group with 2\u2010years OS of 92.9% and a high\u2010risk group with 2\u2010years OS of 52.5% (HR 6.57 [3.27\u201313.18],\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.0001). Immune cell signatures could be used as prognostic markers and provided further insights for individualized immunotherapeutic strategies in DLBCL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2905","type":"journal-article","created":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T04:47:29Z","timestamp":1627706849000},"page":"616-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Implication of immune cell signature of tumor microenvironment in diffuse large B\u2010cell lymphoma"],"prefix":"10.1002","volume":"39","author":[{"given":"Hao","family":"Yu","sequence":"first","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Fu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng\u2010Peng","family":"Xu","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3652-9881","authenticated-orcid":false,"given":"Yun\u2010Zeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangsu Key Laboratory of Zoonosis Jiangsu Co\u2010Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses Yangzhou University  Yangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6834-1616","authenticated-orcid":false,"given":"Wei\u2010Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai 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