{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:08:45Z","timestamp":1772118525228,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","award":["R249\u2010A14646\u201019\u2010S70"],"award-info":[{"award-number":["R249\u2010A14646\u201019\u2010S70"]}],"id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Real world evidence is important since most patients cannot be included in randomized clinical trials (RCTs). In a nationwide, cohort of relapsed\/refractory multiple myeloma patients treated with daratumumab (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0635), we retrospective studied patients treated with carfilzomib (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0251). Data were collected by audit of medical records. We compared characteristics of patients treated with carfilzomib before daratumumab (Car\u2010Da;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0150) and after daratumumab (Da\u2010Car;\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0101) with those not treated with carfilzomib (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a0384). Furthermore, we examined effectiveness and safety of carfilzomib. The group of patients treated with carfilzomib differed from patients not treated with carfilzomib in the following parameters: They were younger, more were treated up\u2010front with high dose melphalan and autologous stem cell transplantation (HDM\u2010ASCT)and had relapse within 18 months thereafter, and more had high\u2010risk cytogenetic abnormalities (CA) and amplification 1q (amp1q). In patients treated with Car\u2010Da, 30.3% had high\u2010risk CA and 30.1% had amp1q and in Da\u2010Car it was 43.3% and 41%, respectively. In the Car\u2010Da cohort, 34.4% experienced early relapse after HDM\u2010ASCT versus 47.4% in the Da\u2010Car cohort. The percentage of patients with very good partial remission was higher in patients treated with Car\u2010Da compared to Da\u2010Car (31.7% vs. 17.4%). The median duration of treatment and time to next treatment (TNT) of Car\u2010Da\/Da\u2010Car were 4.6\/4.3 months and 7.1\/4.3 months and only a trend toward superior TNT for Car\u2010Da was found (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.06). Toxicity of carfilzomib was the same as reported in RCT. A similar poor TNT of daratumumab was found when used before (5.6 months) or after carfilzomib (4.9 months). In this cohort of patients with sequential treatment with carfilzomib and daratumumab or vice versa, a high percentage of patients were high\u2010risk by CA, amp1q, and early relapse after HDM\u2010ASCT. Outcome of Car\u2010DA and outcome of Da\u2010Car were equally poor. These patients should be considered for new promising treatment strategies.\n                  <\/jats:p>","DOI":"10.1002\/hon.2906","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T01:01:22Z","timestamp":1627952482000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Outcome of treatment with carfilzomib before and after treatment with daratumumab in relapsed or refractory multiple myeloma patients"],"prefix":"10.1002","volume":"39","author":[{"given":"Karen Louise","family":"H\u00f8jholt","sequence":"first","affiliation":[{"name":"Department of Haematology Rigshospitalet Copenhagen University  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Gregersen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agoston Gyula","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Hospital  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias Wirenfeldt","family":"Klausen","sequence":"additional","affiliation":[{"name":"Department of Haematology Herlev University Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette B\u00f8egh","family":"Levring","sequence":"additional","affiliation":[{"name":"Department of Haematology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Preiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Odense University Hospital  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten","family":"Helleberg","sequence":"additional","affiliation":[{"name":"Department of Haematology Herlev University Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Fredslund","family":"Breinholt","sequence":"additional","affiliation":[{"name":"Department of Pathology Herlev University Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1754-5336","authenticated-orcid":false,"given":"Emil","family":"Hermansen","sequence":"additional","affiliation":[{"name":"Department of Haematology Zealand University Hospital  Roskilde Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise Mette","family":"Rahbek Gjerdrum","sequence":"additional","affiliation":[{"name":"Department of Pathology Zealand University Hospital  Roskilde Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren Thorgaard","family":"B\u00f8nl\u00f8kke","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eigil","family":"Kjeldsen","sequence":"additional","affiliation":[{"name":"Department of Haematology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine Fladeland","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Haematology Vejle Hospital  Vejle Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Manuela","family":"Teodorescu","sequence":"additional","affiliation":[{"name":"Department of Haematology Aalborg University Hospital  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Haematology Regionshospitalet Holstebro  Holstebro Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Casper","family":"Strandholdt","sequence":"additional","affiliation":[{"name":"Department of Haematology Esbjerg Hospital  Esbjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette Klarskov","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Rigshospitalet  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2131-731X","authenticated-orcid":false,"given":"Annette 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