{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:35:42Z","timestamp":1789576542461,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T00:00:00Z","timestamp":1629244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010434","name":"\u201cla Caixa\u201d Foundation","doi-asserted-by":"publisher","award":["PI19\/01828"],"award-info":[{"award-number":["PI19\/01828"]}],"id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002809","name":"Generalitat de Catalunya","doi-asserted-by":"publisher","award":["2017 SGR288"],"award-info":[{"award-number":["2017 SGR288"]}],"id":[{"id":"10.13039\/501100002809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Despite high complete remission (CR) rates with frontline therapy, relapses are frequent in adults with T\u2010cell acute lymphoblastic leukemia (T\u2010ALL) with limited salvage options. We analyzed the outcomes and prognostic factors for CR to salvage therapy and overall survival (OS) of patients with R\/R T\u2010ALL included in two prospective measurable residual disease\u2010oriented trials. Seventy\u2010five patients (70 relapsed, 5 refractory) were identified. Relapses occurred in bone marrow, isolated or combined in 50 patients, and in the central nervous system (CNS; isolated or combined) in 20. Second CR was attained in 30\/75 patients (40%). Treatment with FLAG\u2010Ida and isolated CNS relapse were independently associated with a higher CR rate after first salvage therapy. The median OS was 6.2 (95% confidence interval [CI], 3.9\u20138.6) months, with a 4\u2010year OS probability of 18% (95% CI, 9%\u201327%). No differences in survival were observed according to the treatment with hematopoietic stem cell transplantation in patients in CR after first salvage therapy. Multivariable analysis showed\n                    <jats:italic>a<\/jats:italic>\n                    \u226512\u2010month interval between first CR and relapse, CR after first salvage therapy and isolated CNS relapse as favorable prognostic factors for OS with hazard ratios (HR) (95% CI) of 1.931 (1.109\u20133.362), 2.958 (1.640\u20135.334), and 2.976 (1.157\u20137.655), respectively. This study confirms the poor outcomes of adults with R\/R T\u2010ALL among whom FLAG\u2010Ida was the best of the rescue therapies evaluated. Late relapse, CR after first rescue therapy and isolated CNS relapse showed prognostic impact on survival. More effective rescue therapies are needed in adults with R\/R T\u2010ALL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2910","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T07:43:41Z","timestamp":1629272621000},"page":"529-538","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Outcomes and prognostic factors of adults with refractory or relapsed T\u2010cell acute lymphoblastic leukemia included in measurable residual disease\u2010oriented trials"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1042-6024","authenticated-orcid":false,"given":"Josep\u2010Maria","family":"Ribera","sequence":"first","affiliation":[{"name":"Hematology Department Institut Catal\u00e0 d\u2019Oncologia Hospital Germans Trias i Pujol Josep Carreras Research Institute Universitat Aut\u00f2noma de Barcelona  Barcelona 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