{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:42Z","timestamp":1772118642032,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T00:00:00Z","timestamp":1629849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K08345"],"award-info":[{"award-number":["18K08345"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study characterized the outcomes of patients who underwent hematopoietic cell transplantation (HCT) for transformed follicular lymphoma (tFL), and clarified the association of low\u2010dose anti\u2010thymocyte globulin use with outcomes after allogeneic HCT. The retrospective study cohort included 74 consecutive patients who underwent autologous (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a023) or allogeneic (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a051) HCT at our center from 2000 to 2017. Compared with the allogeneic HCT group, the autologous HCT group underwent fewer systemic regimens before HCT (median 2 vs. 5,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.001) and were more likely to have chemosensitive disease at HCT (100% vs. 82%,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.05), while age, sex and HCT\u2010specific comorbidity index were similar between the two groups. With a median follow\u2010up of 5.8 years among survivors, the 5\u2010year probability of progression\u2010free survival was 64% after autologous HCT and 55% after allogeneic HCT (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.21). The 5\u2010year cumulative incidence of non\u2010relapse mortality was 0% after autologous HCT and 9.5% after allogeneic HCT (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.062). The 5\u2010year cumulative incidence of disease progression was similar between autologous and allogeneic HCT (36% vs. 36%, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.88). In the allogeneic HCT group, the use of low\u2010dose anti\u2010thymocyte globulin was associated with a lower incidence of severe acute GVHD but not with an increased risk of mortality or disease progression. More than half of patients with early phase chemosensitive tFL and approximately half of those with advanced\u2010phase tFL achieved long\u2010term progression\u2010free survival with autologous and allogeneic HCT, respectively. Disease progression was the major cause of treatment failure after both types of HCT. Further strategies are needed to reduce the risk of disease progression.\n                  <\/jats:p>","DOI":"10.1002\/hon.2917","type":"journal-article","created":{"date-parts":[[2021,8,25]],"date-time":"2021-08-25T07:40:03Z","timestamp":1629877203000},"page":"650-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of hematopoietic cell transplantation for transformed follicular lymphoma"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8705-7143","authenticated-orcid":false,"given":"Hanae","family":"Ida","sequence":"first","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4881-0427","authenticated-orcid":false,"given":"Yoshihiro","family":"Inamoto","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2423-9978","authenticated-orcid":false,"given":"Suguru","family":"Fukuhara","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko Miyagi","family":"Maeshima","sequence":"additional","affiliation":[{"name":"Department of Pathology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneaki","family":"Hirakawa","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatomo","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung\u2010Won","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Izutsu","sequence":"additional","affiliation":[{"name":"Department of Hematology National Cancer Center Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Hematopoietic Stem Cell Transplantation National Cancer Center Hospital  Tokyo Japan"},{"name":"Course of Advanced Clinical Research of Cancer Juntendo University Graduate School of Medicine  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.48.3990"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000258"},{"key":"e_1_2_10_4_1","first-page":"CD007678","article-title":"High\u2010dose therapy with autologous stem cell transplantation versus chemotherapy or immuno\u2010chemotherapy for follicular lymphoma in adults","volume":"1","author":"Schaaf M","year":"2012","journal-title":"Cochrane Database Syst 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