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However, it has not yet been established whether any of them globally outperforms the others. We evaluated the clinical utility and statistical performance of the five most widely used clinical scores (IPI, ILI, FLIPI, FLIPI2, PRIMA\u2010PI) in a single\u2010center series of 414 grade 1\u20103A FL patients diagnosed in the rituximab era. Overall concordance (proportion of patients allocated to the same risk category by all five RS) was 24%. FLIPI and FLIPI2 were predictive of time to first treatment. All five scores were predictive of response, POD24, progression\u2010free, and OS, while only FLIPI predicted HT. IPI identified a small subset (7%) of truly high\u2010risk patients (10\u2010year OS of 16%). In subgroup analyses, we showed that ILI is useful in the prognostication of limited\u2010disease patients, and PRIMA\u2010PI is an age\u2010independent score that can identify a high\u2010risk subset of older patients. Performance metrics were slightly better for IPI in terms of calibration (Harrell's c\u2010index 0.73), without major differences among RS regarding other parameters. Although the incorporation of molecular and imaging data will continue to refine the stratification of FL patients, FLIPI remains the most powerful clinical prognostic index in the rituximab era, predicting the greatest number of endpoints.<\/jats:p>","DOI":"10.1002\/hon.2922","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T02:29:49Z","timestamp":1631068189000},"page":"639-649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prognostic ability of five clinical risk scores in follicular lymphoma: A single\u2010center evaluation"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9528-4971","authenticated-orcid":false,"given":"Pablo","family":"Mozas","sequence":"first","affiliation":[{"name":"Department of Hematology Hospital Cl\u00ednic de Barcelona  Barcelona 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