{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:42:37Z","timestamp":1787586157637,"version":"build-2736575974"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002635","name":"Inha University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Peripheral T\u2010cell lymphomas (PTCLs) are known to have an aggressive clinical course and grave prognosis. Several recommended first\u2010line treatment regimens are available, but identification of the superior treatment remain elusive. We conducted a systematic review and meta\u2010analysis to determine which study\u2010level factors and group of regimens affect survival outcomes. The MEDLINE, Embase, and Cochrane databases were searched from inception to January 2021, and phase II or III clinical studies evaluating the efficacy of chemotherapy regimens were included. Random effects models were used to estimate 3\u2010year overall survival rate, complete remission rate, and subgroup differences. Meta\u2010regressions were carried out with adjustments for relevant covariates. Overall, 34 cohorts from 28 studies comprising 1424 PTCL patients were included in the pooled analysis. Chemotherapy regimens were divided into four groups: cyclophosphamide, doxorubicin, vincristine, prednisone (CHOP), CHOP plus etoposide, gemcitabine\u2010based, and others. The pooled 3\u2010year overall survival rate was 0.49 (95% confidence interval [CI] 0.43\u20130.54) for CHOP, 0.61 (95% CI 0.52\u20130.70) for CHOP plus etoposide, 0.39 (95% CI 0.30\u20130.47) for gemcitabine\u2010based, and 0.61 (95% CI 0.44\u20130.78) for others. CHOP plus etoposide was significantly better than CHOP, with the latter used as a reference (coefficient of 0.11;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.035), with adjustment for the proportion of International Prognostic Index score 4\u20105 in meta\u2010regression analysis. Although grossly divided groups were pooled and analyzed, among four regimen groups for frontline PTCL treatment CHOP plus etoposide showed better survival than CHOP.\n                  <\/jats:p>","DOI":"10.1002\/hon.2924","type":"journal-article","created":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T15:28:22Z","timestamp":1630942102000},"page":"664-673","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Comparison of first\u2010line treatments of peripheral T\u2010cell lymphoma according to regimen: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6013-7477","authenticated-orcid":false,"given":"Jinchul","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Department of Hematology\u2010Oncology Inha University College of Medicine and Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhyun","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Hematology\u2010Oncology Inha University College of Medicine and Hospital  Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonggyu","family":"Byeon","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Department of Internal Medicine Chungbuk National University Hospital Chungbuk National University College of Medicine  Cheongju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won Seog","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2776-4401","authenticated-orcid":false,"given":"Seok Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Hematology\u2010Oncology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul Korea"},{"name":"Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University School of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.16.4558"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.186577"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0053"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv201"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13202"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32984-2"},{"key":"e_1_2_8_8_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology. T\u2010Cell Lymphoma (Version 1. 2021)"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.15.2008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.52.6.377"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2013-203104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-074641"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdn022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.4870"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08329.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq635"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.2719"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.061507"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.06.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-011-1711-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1880-4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.742521"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27733"},{"key":"e_1_2_8_24_1","first-page":"1416","article-title":"CHOEP\u201021 chemotherapy for newly diagnosed nodal peripheral T\u2010cell lymphomas (PTCLs) in Maharaj Nakorn Chiang Mai Hospital","volume":"96","author":"Rattarittamrong E","year":"2013","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2014.79"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2013.816700"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13628"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(15)00023-X"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2136"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13855"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.131151"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv624"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.167742"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30039-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-018-0294-2"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3488-1"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00739-0"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0838-5"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0554-3"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199304083281404"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-573089"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-019-03694-y"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2017010819"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu443"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S189825"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404306"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31861"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx787"},{"key":"e_1_2_8_49_1","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin's lymphomas. Groupe d'Etudes des Lymphomes de l'Adulte (GELA)","volume":"92","author":"Gisselbrecht C","year":"1998","journal-title":"Blood"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-09-310342"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008418727472"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2924","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,13]],"date-time":"2025-03-13T06:02:37Z","timestamp":1741845757000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,6]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/hon.2924"],"URL":"https:\/\/doi.org\/10.1002\/hon.2924","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.2924\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2924\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2924\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2924\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2924\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,6]]},"assertion":[{"value":"2021-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}