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Here, we report on the expression pattern of the LINC00152 in normal B cells and Chronic Lymphocytic Leukemia B cell clones. Higher LINC00152 levels were consistently observed in memory B cell populations when compared to na\u00efve B cells in the normal tissues analyzed [peripheral blood (PB), tonsils, and spleen]. In addition, independent stimulation via Immunoglobulins (IG), CD40, or Toll\u2010like Receptor 9 (TLR9) upregulated LINC00152 in PB B cells. The expression of LINC00152 in a cohort of 107 early stage Binet A CLL patients was highly variable and did not correlate with known prognostic markers or clinical evolution. TLR9 stimulation, but not CD40 or IG challenge, was able to upregulate LINC00152 expression in CLL cells. In addition, LINC00152 silencing in CLL cell lines expressing LINC00152 failed to induce significant cell survival or apoptosis changes. These data suggest that, in normal B cells, the expression of LINC00152 is regulated by immunomodulatory signals, which are only partially effective in CLL cells. However, LINC00152 does not appear to contribute to CLL cell expansion and\/or survival in a cohort of newly diagnosed CLL patients.<\/jats:p>","DOI":"10.1002\/hon.2938","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T12:39:02Z","timestamp":1634906342000},"page":"41-48","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-0213","authenticated-orcid":false,"given":"Serena","family":"Matis","sequence":"first","affiliation":[{"name":"Molecular Pathology Unit IRCCS Ospedale Policlinico San Martino  Genoa 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9047-5912","authenticated-orcid":false,"given":"Antonino","family":"Neri","sequence":"additional","affiliation":[{"name":"Fondazione C\u00e0 Granda IRCCS Hematology Ospedale Maggiore Policlinico Milano  Milan Italy"},{"name":"Department of Oncology and Hemato\u2010oncology University of Milan  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5256-0726","authenticated-orcid":false,"given":"Massimo","family":"Gentile","sequence":"additional","affiliation":[{"name":"Hematology Unit A.O. of Cosenza  Cosenza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fortunato","family":"Morabito","sequence":"additional","affiliation":[{"name":"Biotechnology Research Unit AO  Cosenza Italy"},{"name":"Hematology and Bone Marrow Transplant Unit, Hemato\u2010Oncology Department Augusta Victoria Hospital  East Jerusalem 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