{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:09:38Z","timestamp":1772118578197,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,11,10]],"date-time":"2021-11-10T00:00:00Z","timestamp":1636502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Hematological Oncology"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Mantle cell lymphoma (MCL) is a rare, often aggressive type of B\u2010cell lymphoma with poor survival and no cure. Cancer and cancer treatment has a negative impact on health\u2010related quality of life (HRQOL) both during active disease and in the long term, and improvement of HRQOL is a crucial objective of cancer therapy in older patients and no curative intent. Baseline HRQOL has in other lymphoma populations been shown to be predictive of outcome. Here, we explored HRQOL, and its association with survival, by the EORTC QLQ\u2010C30 questionnaire, before, during and after chemotherapy in a patient cohort with MCL, treated within the NLG\u2010MCL4 trial, designed to evaluate the addition of lenalidomide (LEN) to rituximab\u2010bendamustine (R\u2010B) as first\u2010line treatment. Fifty\u2010one patients were enrolled, median age was 71\u00a0years (range 62\u201384), 37 were men (73%). Pre\u2010treatment HRQOL was similar to scores from the reference population with healthy individuals. During treatment, HRQOL deteriorated, but reverted to the same level as the reference population after treatment. There was a correlation between physical function (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.001) and role function (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.006) at baseline and WHO performance status, but not with other clinical or genetic prognostic factors. None of the baseline factors were predictive for treatment related to HRQOL in this cohort. Pre\u2010treatment physical (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.011) and role function (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.032) were independent factors associated with overall survival, and physical function (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.002) was also associated with progression free survival. These findings may possibly be used to design support during treatment and improve rehabilitation. Further investigations are needed for assessment of long\u2010term HRQOL.\n                  <\/jats:p>","DOI":"10.1002\/hon.2940","type":"journal-article","created":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T21:54:25Z","timestamp":1635458065000},"page":"23-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pre\u2010treatment health\u2010related quality of life parameters have prognostic impact in patients &gt;65\u00a0years with newly diagnosed mantle cell lymphoma: The Nordic Lymphoma Group MCL4 (LENA\u2010BERIT) experience"],"prefix":"10.1002","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4873-4797","authenticated-orcid":false,"given":"\u00c5sa","family":"Lindberg","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Lund University  Lund Sweden"},{"name":"Division of Medicine Halland Hospital  Halmstad Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian Winther","family":"Eskelund","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Centre, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Albertsson\u2010Lindblad","sequence":"additional","affiliation":[{"name":"Division of Oncology Lund University  Lund Sweden"},{"name":"Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2699-3357","authenticated-orcid":false,"given":"Arne","family":"Kolstad","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Laurell","sequence":"additional","affiliation":[{"name":"Department of Oncology Akademiska University Hospital  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riikka","family":"R\u00e4ty","sequence":"additional","affiliation":[{"name":"Department of Haematology Helsinki University Hospital  Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten","family":"Gr\u00f8nb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Centre, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8160-5647","authenticated-orcid":false,"given":"Christian Hartmann","family":"Geisler","sequence":"additional","affiliation":[{"name":"Department of Haematology Rigshospitalet  Copenhagen Denmark"},{"name":"Biotech Research and Innovation Centre, Faculty of Health Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4509-6707","authenticated-orcid":false,"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[{"name":"Division of Oncology Lund University  Lund Sweden"},{"name":"Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-04-348367"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.08.133"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djk152"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25487"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1326034"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2067"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980201)82:3<567::AID-CNCR20>3.0.CO;2-Z"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24797"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095331"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.194399"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01294"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701769"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03520250075037"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(18)30051-6"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1385\/MO:18:1:85"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29119"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.1684"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-017-3698-4"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.207"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2522"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-03-704023"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5858\/1999-123-1182-MCL"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.08.007"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.3.1188"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(96)00428-3"},{"key":"e_1_2_10_28_1","volume-title":"EORTC QLQ\u2010C30 Scoring Manual","author":"Fayers P","year":"2001"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(98)00136-1"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6337-2"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2016.1267404"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.13067"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"117","article-title":"Quality of life among patients with hematological cancer in a Malaysian hospital","volume":"66","author":"Priscilla D","year":"2011","journal-title":"Med J Malays"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-016-2844-6"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx413"}],"container-title":["Hematological Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2940","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hon.2940","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hon.2940","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T19:24:43Z","timestamp":1692991483000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hon.2940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,10]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10.1002\/hon.2940"],"URL":"https:\/\/doi.org\/10.1002\/hon.2940","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/HON.2940\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2940\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2940\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/HON.2940\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0278-0232","1099-1069"],"issn-type":[{"value":"0278-0232","type":"print"},{"value":"1099-1069","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,10]]},"assertion":[{"value":"2021-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}